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佩奥尼亚雷迪克斯 (Paeoniae Radix Rubra) 对通过生物信息学和肠道微生物群来降低脂质的作用

Zhi Lin¹, Haiqing Luo², Shuang Pan¹

¹College of Pharmacy, Changchun University of Chinese Medicine, 1035 Boshuo Road, Changchun, 130117, Jilin, China.

Scientific reports

|July 2, 2025

概括

在治疗超脂血症方面,Paeoniae Radix Rubra通过改善脂质水平和恢复肠道微生物群,显示出有前途. 它可以通过与美酸途径中的关键蛋白相互作用来降低胆固醇合成.

科学领域:

药理学药理学是指药理学的学科.
代谢障碍代谢障碍代谢障碍
微生物组研究微生物组研究

背景情况:

超脂血症的特征是脂质水平异常,显著增加心血管疾病的风险.
传统的草药越来越多地被探索用于管理像高脂血症这样的代谢障碍.

研究的目的:

为了研究Paeoniae Radix Rubra的低脂效应.
在高脂肪饮食诱导的超脂血症模型中评估其对肠道微生物群组成的影响.
识别潜在的生物活性化合物和分子标.

主要方法:

使用超高性能液体染色学与四极轨道式质谱学 (UHPLC-QE-MS/MS) 结合用于化学成分识别.
采用生物信息学,网络药理学和分子对接来进行化合物和标的虚拟查.
在高脂肪饮食模型中评估了低脂性,肝保护性和肠道微生物群调节效应.

主要成果:

鉴定了N和 (E)-5-[(1S,4aR,8aR)-2-formyl-5,5,8a-trimethyl-1,4,4a,6,7,8-hexahydronaphthalen-1-yl]-3-(acetoxymethyl) -2-酸作为潜在的活性化合物.
佩奥尼亚雷迪克斯 (Paeoniae Radix Rubra) 显示出显著的低脂性,肝保护性和肠道微生物群恢复性作用.
潜在的机制涉及通过与P53,HMGCR和SREBP2等蛋白质的相互作用影响美酸盐路径,减少胆固醇合成.

结论:

佩奥尼亚雷迪克斯 (Paeoniae Radix Rubra) 在高脂血症方面表现出治疗潜力.
它的有效性可能通过调节脂质代谢途径和重塑肠道微生物群来调节.
对其活性化合物和机制进行进一步的研究是必要的,以获得临床应用.

关键词:

它们是Paeoniae Radix Rubra 种类.生物信息学是一种生物信息学.我们的肠道微生物群.超脂血症是因为超脂血症梅瓦诺酸的途径

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