细胞受体MERTK和AXL在Progranulin缺乏FTD中的对立作用

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Modified Yeast-Two-Hybrid System to Identify Proteins Interacting with the Growth Factor Progranulin
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Published on: January 17, 2012

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Claire Dudley Clelland1,2, Li Fan3, Rowan Saloner4

  • 1Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA. claire.clelland@ucsf.edu.

Communications biology
|July 2, 2025
PubMed
概括

进激素基因 (GRN) 的遗传突变破坏了微质功能,影响了前性痴呆 (FTD) 的发病. 这项研究揭示了GRN,MERTK和AXL相互作用,为神经炎症提供了新的治疗点.

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