深度学习揭示了雄性鱼颜色的复杂遗传结构
Wouter van der Bijl1, Jacelyn J Shu2, Versara S Goberdhan2
1Department of Zoology, Biodiversity Research Centre, University of British Columbia, Vancouver, British Columbia, Canada. wouter@zoology.ubc.ca.
Nature ecology & evolution
|July 2, 2025
概括
雄性古皮的颜色变异是多基因的,许多遗传性特征由基因组中的独立遗传结构控制. 性别相关的颜色变异可能是由Y染色体上的自体基因复制体驱动的.
科学领域:
- 进化生物学 进化生物学
- 遗传学 遗传学 是一个
- 动物行为 动物行为
背景情况:
- 雄性鱼 (Poecilia reticulata) 的色彩表现出非凡的变化,使其成为研究自然和性选择的关键模型.
- 鱼颜色变化的复杂性阻碍了高分辨率的表征和对其遗传结构和维护的理解.
- 之前的研究在完全剖析这种多样性特征的遗传基础方面面临着挑战.
研究的目的:
- 为了确定雄性鱼颜色变化的遗传性和遗传基础.
- 为了阐明控制古皮狗复杂色彩模式的遗传结构.
- 了解这种模型生物体中维持异常多样性的机制.
主要方法:
- 采用卷积神经网络用于高分辨率的男性鱼色彩的表型.
- 进行了选择实验,并利用受控的血统来追踪遗传性.
- 进行全基因组再测序和全基因组关联研究 (GWAS) 以确定遗传位置.
主要成果:
- 毛皮犬的颜色模式是众多遗传特征的复合物,每个特征都有在整个基因组中分布的基本上独立的遗传结构.
- 自体继承的色彩装饰是多基因的,在神经细胞迁移中涉及的基因的显著贡献.
- GWAS的结果表明,从自体转移到Y染色体的基因重复是性别相关的颜色变异的主要来源.
结论:
- 雄性古皮的颜色变化是由一个复杂的多基因系统控制的,具有广泛的遗传影响.
- 自体基因重复的转移到Y染色体提供了一个新的机制来维持与性别相关的特征变异.
- 这些发现为我们更深入地了解了Poecilia reticulata极端表型多样性的遗传基础和进化维护.
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