累积尿酸暴露与代谢功能障碍相关的脂肪肝疾病之间的关联
Yunpeng Li1, Hong Ji1, Fei Tian2
1Department of Hepatobiliary Surgery, Kailuan General Hospital Affiliated to North China University of Science and Technology, Tangshan, 063000, China.
BMC gastroenterology
|July 2, 2025
概括
增加的累积尿酸 (cum UA) 暴露是代谢功能障碍相关脂肪肝疾病 (MAFLD) 的独立风险因素. 较高的UA水平显著增加了发展MAFLD的发病率和风险,特别是在男性和吸烟者中.
科学领域:
- 代谢性疾病研究研究.
- 肝病流行病学 肝病流行病学
- 尿酸代谢和健康 尿酸代谢和健康
背景情况:
- 与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 是一个日益严重的公共卫生问题.
- 累积尿酸 (cum UA) 暴露在MAFLD病原体中的作用需要进一步研究.
- 了解MAFLD的风险因素对于制定有效的预防和治疗策略至关重要.
研究的目的:
- 调查累积尿酸 (cum UA) 暴露与代谢功能障碍相关脂肪肝疾病 (MAFLD) 的发生率之间的关联.
- 为了确定更高的UA水平是否与发展MAFLD的风险增加有关.
- 探索剂量-反应关系,并确定高风险的特定子组.
主要方法:
- 对21,333名员工进行前性队列研究,平均随访时间为6.24年.
- 根据在三次健康检查中测量的累积尿酸水平,参与者被分为四分之一.
- 用多变量调整的Cox比例危险回归和Kaplan-Meier生存分析来评估MAFLD发病率和风险.
主要成果:
- 在累积尿酸暴露和MAFLD风险之间观察到显著的非线性剂量反应关系.
- 较高的累积尿酸四分位数与MAFLD发展的危险比率逐渐增加有关.
- 随着累积尿酸水平的增加,MAFLD的发病密度和累积发病率上升,男性,吸烟者和腹部肥胖患者的发病率显著上升.
结论:
- 累积尿酸暴露被确定为MAFLD的独立风险因素.
- 随着累积尿酸水平的上升,发展MAFLD的发病率和风险都在增加.
- 男性,吸烟者和腹部肥胖症患者具有较高的MAFLD风险,与增加的累积尿酸相关.
相关概念视频
01:24Overview of Lipid Metabolism
2.5K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
2.5K
01:24Chronic Pancreatitis I: Introduction
168
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
168
01:24Chronic Kidney Disease II: Clinical Manifestations
104
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
104
01:28Overview of Fatty Acid Metabolism
31.8K
Lipids also are sources of energy that power cellular processes. Like carbohydrates, lipids are composed of carbon, hydrogen, and oxygen, but these atoms are arranged differently. Most lipids are nonpolar and hydrophobic. Major types include fats and oils, waxes, phospholipids, and steroids.
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
31.8K