hsa_circ_0012138在阻塞性病慢性进展中的诊断价值
Zhichao Huang1, Fei Deng1, Zebin Deng1
1Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.
BMC nephrology
|July 2, 2025
概括
一种新型的循环RNA,hsa_circ_0012138,显示出作为预测阻塞性病患者功能恢复的生物标志物具有前途. 这一发现有助于为维护功能做出手术决定.
科学领域:
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 阻塞性病 (ON) 导致逐渐的功能障碍和慢性病.
- 预测ON患者的功能可逆性对于治疗决策至关重要,特别是在晚期诊断时.
- 循环RNAs (circRNAs) 参与了ON的发病,但它们在功能可逆性中的具体作用尚不清楚.
研究的目的:
- 为了研究hsa_circ_0012138在阻塞性病中的表达.
- 评估hsa_circ_0012138作为预测ON患者功能可逆性的生物标志物的潜力.
主要方法:
- 用RT-qPCR和RNA-光 in situ杂交 (RNA-FISH) 来确定hsa_circ_0012138的表达.
- 基因组丰富分析 (GSEA) 用于生物信息学分析.
- 接收器操作特征 (ROC) 曲线被用于临床数据分析.
主要成果:
- hsa_circ_0012138的表达在脏组织中被确定,并在ON患者的尿液中检测到.
- GSEA建议hsa_circ_0012138可以通过ceRNA机制调节与纤维化相关的基因.
- hsa_circ_0012138在预测功能可逆性方面表现出良好的特异性和敏感性,表现优于NAGL.
结论:
- hsa_circ_0012138是ON患者功能可逆性的潜在预后标志物.
- 这种生物标志物可以帮助进行节约手术的外科决策.
- 进一步的研究可以验证hsa_circ_0012138在治疗阻塞性病的临床应用.
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