系统性免疫炎症指数和血液透析患者的系统性炎症反应指数的预后影响
1Department of Hemodialysis Center, The Traditional Chinese Medicine Hospital of Pujiang County, Pujiang, Zhejiang, 322200, China.
BMC nephrology
|July 2, 2025
概括
血液透析 (HD) 患者的高死亡率与炎症有关. 系统性免疫炎症指数 (SII) 和系统性炎症反应指数 (SIRI) 的升高预测了HD患者因所有原因死亡,心血管疾病和感染的风险增加.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 免疫学 免疫学 免疫学
- 心血管医学 心血管医学
背景情况:
- 接受血液透析 (HD) 的患者的死亡率很高,主要是由于心血管疾病 (CVD),感染和透析中止.
- 系统性炎症是导致HD患者这些不良结果的重要因素.
研究的目的:
- 调查系统性免疫炎症指数 (SII) 和系统性炎症反应指数 (SIRI) 与疾病发病患者死亡率之间的关联.
- 评估SII和SIRI对所有原因,心血管疾病和感染相关死亡率的预后价值.
主要方法:
- 对1190名HD患者的回顾性分析.
- 卡普兰-梅尔生存曲线,考克斯回归和受限制立方脊柱 (RCS) 模型被用于评估死亡风险.
- 采用接收器操作特征 (ROC) 曲线来确定预测准确性.
主要成果:
- 较高的SIRI和SII四分位数与所有原因,心血管疾病和感染相关死亡率的风险增加有显著联系.
- RCS分析表明SII,SIRI和死亡风险之间存在非线性关系.
- 与SII相比,SIRI显示出更高的预后价值和风险分层.
结论:
- 升高的SII和SIRI水平与HD患者的死亡风险增加有关.
- 在这一群体中,SIRI成为更可靠的死亡率预测指标.
- 需要进一步的研究来阐明潜在的机制并验证这些发现.
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