达拉图穆马布诱导的急性闭角光眼:骨髓移植作为可能的危险因素和化作为潜在的解决方案
Cansu Yuksel Elgin1, Ahmet Fırat Atseven2, Ofeliya Mammadzada2
1Istanbul University-Cerrahpasa, Istanbul, Türkiye. cansu.elgin@iuc.edu.tr.
BMC ophthalmology
|July 2, 2025
概括
一名患有T细胞急性淋巴细胞白血病的患者在治疗达拉图姆巴后出现了急性角度闭眼光. 骨髓移植史是一个危险因素,而氨酸前期治疗可以预防复发.
科学领域:
- 在瘤学瘤学.
- 眼科医生 眼科 眼科
背景情况:
- 一名29岁的女性患有复发的T细胞急性淋巴细胞白血病 (T-ALL) 接受了达拉图穆马布输液.
- 该患者有骨髓移植病史,并先前接受过头部放射治疗.
- 她在输液后不久就出现了眼睛疼痛和视力模糊的急性症状.
研究的目的:
- 为了报告一种罕见的急性角闭眼光眼 (AACG) 病例,该病例是达拉图巴治疗的次要病例.
- 为了确定潜在的风险因素和有效的管理策略对这种不良事件.
主要方法:
- 临床病例介绍和眼科检查.
- 超声波生物显微镜用于评估眼睛结构.
- 使用局部药物和氨酸前期治疗进行管理.
主要成果:
- 患者呈现双边AACG和升高的眼内压力.
- 超声波生物显微镜揭示了状腺恶性旋转和冠状腺溢液,归因于daratumumab.
- 通过局部药物成功管理和通过氨酸前期治疗预防复发.
结论:
- 达拉图穆马布输液可以诱导AACG,特别是在有骨髓移植病史的患者中.
- 由于状体的变化而导致的冠状腺溢出是可能的机制.
- 阿特罗平前期治疗是一种有效的策略,可以预防达拉图穆马布诱导的AACG.
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