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葡萄种子提取物对引起的常见鱼 (Cyprinus carpio) 激素毒性的缓解作用

Nuh Korkmaz¹, Kenan Erdoğan², Gül Nihal Örün³

¹Department of Biology, Faculty of Engineering and Natural Sciences, Osmaniye Korkut Ata University, Osmaniye, Turkey. korkmazhun@gmail.com.

BMC veterinary research

|July 2, 2025

概括

葡萄种子提取物 (GSE) 通过减轻荷尔蒙干扰,显示出对普通的毒性有保护潜力. 虽然急性有效,但对生长激素的一些亚慢性影响仍然存在,这表明GSE是天然的水产养殖解决方案.

科学领域:

水生物质毒理学研究
内分泌学在内分泌学.
鱼类生理学鱼类生理学

背景情况:

(Cd) 是一种有毒的重金属,通过破坏内分泌和代谢功能,影响水生生物.
鱼类中的CD生物积累可能导致荷尔蒙调节受损,增长抑制,压力和甲状腺功能障碍.
自然化合物被探索为减轻水产养殖中重金属毒性的替代方案.

研究的目的:

研究葡萄 (Vitis vinifera L.) 种子提取物 (GSE) 对引起的常见鱼 (Cyprinus carpio L.) 激素干扰的保护作用.
评估GSE在暴露后对生长激素,压力激素 (皮质醇) 和甲状腺激素 (T3,T4) 的影响.

主要方法:

常见鱼在急性 (4天) 和次慢性 (30天) 期间暴露于 (20ppb) 和/或GSE (5或10 mg/kg).
鱼类被分为七个组:对照组,载体组,Cd-only组,GSE-only组 (两剂),Cd+GSE组 (两剂).
测量了激素水平 (生长激素,IGF-1,TSH,T3,T4,皮质醇),以评估毒性和保护作用.

主要成果:

暴露显著改变了激素水平,降低了生长激素,IGF-1,TSH和T3,同时增加了皮质醇和T4.
GSE治疗部分减轻了Cd诱导的影响,改善了生长激素和IGF-1,降低了皮质醇,增加了自由T3,特别是在急性阶段.
一些荷尔蒙干扰,特别是减少生长激素,在亚慢性暴露中持续存在,尽管给予了GSE.

结论:

葡萄种子提取物显示出作为天然保护剂的潜力,可以防止鱼类对的毒性.
GSE可能提供一种可行的替代策略,以减轻重金属在水产养殖中的不良影响.
可能需要进一步的研究来优化GSE在次慢性重金属暴露场景中的疗效.

关键词:

鱼 (Cyprinus carpio) 是一个有趣的植物.葡萄酒 (Vitis vinifera) 是一种葡萄酒.在ACTH-皮质醇.是的组成部分.在GH/IGF-1中.甲状腺激素甲状腺激素

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