母亲的免疫介导疾病和后代的ADHD风险
Kjersti Mæhlum Walle1,2, Kristin Gustavson3,4, Siri Mjaaland5
1PsychGen Centre for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, P. O. Box 222 Skøyen, Oslo, 0213, Norway. k.m.walle@psykologi.uio.no.
怀孕期间母亲的免疫状况会增加后代的ADHD风险,这表明它对胎儿发育有直接影响. 父亲的喘也与ADHD有关,表明这种机制的潜在例外.
科学领域:
- 生殖免疫学 生殖免疫学
- 神经发育障碍 神经发育障碍
- 围产期流行病学 围产期流行病学
背景情况:
- 怀孕期间母亲的免疫介导疾病与后代注意力缺陷/多动症 (ADHD) 风险的增加有关.
- 在这种关联中,母亲的炎症反应与共享遗传学的作用尚未完全理解.
- 父亲免疫状况被用作负控制来区分这些因素.
研究的目的:
- 调查怀孕期间母亲免疫介导疾病与后代ADHD风险之间的关联.
- 探索母亲免疫反应与遗传因素的贡献,使用父亲免疫状况作为对照.
主要方法:
- 一项前性队列研究,将挪威母亲,父亲和儿童队列研究 (MoBa) 与国家卫生登记处联系起来.
- 评估了104,270对母婴对母亲过敏和其他免疫介导疾病的产前暴露.
- 利用考克斯的比例危险模型来估计ADHD风险,直到18岁,与父亲的免疫状况作为负面对照.
主要成果:
- 母亲的过敏 (HR 1.23) 和其他免疫状况 (HR 1.36) 与后代的ADHD风险增加有关.
- 特定的孕产妇疾病,如喘 (HR 1.47),过敏 (HR 1.20) 和克罗恩病 (aHR 1.95) 显示出显著的关联.
- 父亲喘 (aHR 1.26) 也与后代的ADHD风险有显著的关联,与大多数其他父亲疾病不同.
结论:
- 孕产妇的免疫中介状况与后代多动症的风险增加有关,这表明它对胎儿发育有直接影响.
- 这些发现表明,未测量的遗传混并不能完全解释观察到的关联.
- 母性喘与后代ADHD的关联,以及父性喘,表明潜在的共享机制超出了直接的母性影响.
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