对具有抗微生物潜力的天然产品对世卫组织优先病原体进行系统审查
SeyedAhmad SeyedAlinaghi1,2, Esmaeil Mehraeen3, Pegah Mirzapour1
1Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran.
European journal of medical research
|July 2, 2025
概括
自然产品对抗抗生素耐药细菌具有显著的抗微生物作用. 对这些植物衍生化合物的进一步研究对于打击抗菌素耐药性 (AMR) 是必不可少的.
科学领域:
- 药理学和微生物学
- 自然产品化学 自然产品化学
- 药用植物研究 药用植物研究
背景情况:
- 抗菌素耐药性 (AMR) 是日益严重的全球卫生危机,导致治疗失败和死亡率增加.
- 世界卫生组织 (WHO) 优先考虑了抗生素耐药细菌,强调迫切需要新型抗菌剂.
- 自然产品是发现新抗菌化合物的重要和未被充分探索的资源.
研究的目的:
- 系统地审查关于天然产品对抗抗生素耐药病原体的抗菌作用的原始研究.
- 确定关键的植物衍生化合物及其在对抗WHO优先级耐药细菌中的有效性.
- 评估天然产品作为抗抗菌素耐药性的治疗剂的潜力.
主要方法:
- 使用PUBMED/MEDLINE,WEB OF SCIENCE和SCOPUS数据库进行系统审查的方法.
- 在2024年5月5日进行的搜索,在战略开发研究图书馆员的协助下进行搜索.
- 使用Rayyan和Endnote选标题和摘要,专注于风险估计和95%置信区间的研究.
主要成果:
- 总共审查了2014年至2024年间发表的290项临床试验.
- 研究主要集中在来自中东,南美洲和非洲的植物上.
- 类化合物,黄类化合物 (24.8%),类化合物,类化合物,类化合物,类化合物和类化合物被确定为具有抗氧化和细胞毒性质的关键生物活性化合物,用于对抗病原体,如Pseudomonas aeruginosa,大肠杆菌,肺炎菌,沙门氏菌和黄金葡萄球菌.
结论:
- 自然产品,特别是来自区域药用植物的天然产品,对抗生素耐药性病原体具有显著的治疗潜力.
- 像黄类的生物活性化合物具有抗氧化和细胞毒性,可以增强现有的抗生素.
- 对这些植物衍生化合物的进一步研究对于开发抗生素耐药性的替代策略至关重要.
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