乳酸和乳酸化:关于纤维化病原和治疗方向的新观点
Huanwei Liang1, Linlin Xu2,3, Yi Yang4,5
1Department of Nephrology, Center for Regeneration and Aging Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, 322000, China.
Journal of translational medicine
|July 2, 2025
概括
乳酸及其修饰,乳糖化,是纤维化发展的关键因素. 针对这些代谢过程为抗纤维菌疗法提供了有前途的新途径.
科学领域:
- 生物化学 生物化学
- 细胞生物学 细胞生物学
- 病理学 病理学 病理学
背景情况:
- 纤维化是一个重大的全球健康挑战,代表慢性疾病中的异常组织修复.
- 代谢重编程,特别是涉及乳酸,越来越多地被认为是纤维化病原体.
- 乳酸作为代谢信使,影响细胞间通信和组织重塑.
研究的目的:
- 审查关于乳酸和乳化在纤维化中的作用的最新研究.
- 突出乳化作为纤维化的潜在治疗点.
- 探索向乳酸代谢和乳糖化的临床应用.
主要方法:
- 关于纤维化研究近期进展的文献综述.
- 分析乳酸代谢和乳化作用.
- 整合当前的研究成果.
主要成果:
- 细胞间乳酸转移的失调与纤维化进展有关.
- 乳糖化是一种乳酸驱动的修饰,在纤维化中影响蛋白质功能和基因表达.
- 向乳酸代谢和乳糖化显示出抗纤维化治疗的潜力.
结论:
- 乳酸和乳酸化在纤维化病原发生过程中至关重要.
- 乳化是抗纤维化策略的一个有前途的治疗点.
- 针对乳酸代谢的进一步研究可能会产生新的临床干预措施.
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