生活必需品8与类风湿性关节炎风险之间的关联:一个横截面研究
Longyun Wu1, Jing Wang2, Xueji Wang2
1Department of Interventional Radiology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China.
BMC rheumatology
|July 2, 2025
概括
通过生活必需品8 (LE8) 改善心血管健康与患类风湿性关节炎 (RA) 的风险降低有关. 保持最佳的LE8得分可能有助于预防一般人群中RA的发展.
科学领域:
- 心血管健康 心血管健康
- 类风湿性关节炎的流行病学
- 公共卫生 公共卫生
背景情况:
- 类风湿性关节炎 (RA) 是一种慢性自身免疫性疾病,对公共健康有重大影响.
- 心血管健康 (CVH) 越来越被认为是影响各种慢性疾病的可改变因素.
- 生活必需品8 (LE8) 提供了对心血管健康的全面衡量.
研究的目的:
- 检查生活必需品8 (LE8) 评分与患类风湿性关节炎 (RA) 的风险之间的关联.
- 为了研究单个LE8组件和RA风险之间的关系.
主要方法:
- 从国家健康和营养检查调查 (NHANES) 数据库 (2005-2018) 中对美国成年人 (≥20岁) 的横截面分析.
- LE8及其组成部分 (饮食,体育活动,尼古丁暴露,睡眠健康,BMI,脂质,葡萄糖,血压) 分为低,中等和高CVH分数.
- 多变量逻辑回归和曲线拟合模型评估了LE8分数和RA风险之间的关联和剂量反应关系.
主要成果:
- 总共有17,943名参与者被纳入,其中1233人被诊断为RA.
- 较高的LE8分数 (中等和高) 与较低的分数 (OR=0.66,95%CI=0.62-0.71) 相比,与较低的RA风险显著相关.
- 饮食,尼古丁暴露,睡眠健康,BMI和血糖等个体成分也显示了RA的类似风险模式.
结论:
- 根据Life's Essential 8的测量,心血管健康的提高与风湿性关节炎风险的降低有显著关联.
- 在一般人群中促进理想的CVH得分可能是预防RA的策略.
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