在有铁盐的情况下,吸收动态
Yi Li1, Yongqiang Cheng1, Ning Tang1
1College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China; Beijing Key Laboratory of Functional Food from Plant Resources, Beijing 100083, China.
Food research international (Ottawa, Ont.)
|July 2, 2025
概括
的吸收在乳酸和葡萄酸盐形式中是最高的,即使存在铁. 铁盐可以抑制的吸收,但氧碳酸盐可以改善矿物补充剂的兼容性.
科学领域:
- 营养生物化学 营养生物化学
- 矿物代谢的矿物代谢.
- 细胞生理学 细胞生理学
背景情况:
- 和铁是必不可少的矿物质,经常被联合使用.
- 和铁吸收之间的相互作用会影响营养状况.
- 了解这些相互作用对于优化矿物质补充非常重要.
研究的目的:
- 为了研究不同来源与铁盐的吸收.
- 为了确定乳酸盐和葡萄酸盐离子在铁相互作用中的作用.
- 阐明这些相互作用背后的分子机制.
主要方法:
- 使用Caco-2细胞模型模拟肠道吸收.
- 化,乳酸和葡萄酸的吸收率的比较.
- 评估了铁盐对运输基因表达的影响 (TRPV6,克劳丁-2,calbindin-D9k,DMT1).
- 进行了细胞内吸收的动力学研究.
主要成果:
- 乳酸的吸收率最高,其次是葡萄酸和化.
- 铁盐通常抑制的吸收,根据盐的组合产生不同的效果.
- 铁盐降低了calbindin-D9k和DMT1的表达,但没有显著改变TRPV6或Claudin-2.
- 乳酸盐和葡萄酸盐离子减轻了铁盐对吸收的抑制作用,可能是通过减少氧化应激.
结论:
- 碳酸 (乳酸盐,葡萄酸盐) 在铁的存在下表现出有利的吸收动态.
- 铁盐通过调节细胞内结合蛋白和运输体来影响的吸收.
- 乳酸盐和葡萄酸盐可能会提高和铁补充剂的兼容性.
- 这些发现支持开发更好的矿物质补充策略来治疗共同缺陷.
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