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通过受控的二硫化键裂变优化epigallocatechin gallate-gluten共价凝:为增强功能性质而进行结构定制

Qiu-Yue Ma¹, Qian-Da Xu², Nan Chen¹

¹Antioxidant Polyphenols Team, Department of Food Engineering, Sichuan University, Chengdu 610065, PR China.

Food research international (Ottawa, Ont.)

|July 2, 2025

概括

在质-甲基酸盐 (EGCG) 凝中控制的二硫化键裂解优化了结构和功能. 适度的切割增强了机械强度和EGCG的生物可访问性,为功能性食品成分提供了一个有前途的战略.

科学领域:

食品科学与技术食品科学与技术
生物材料工程生物材料工程
营养学药物开发

背景情况:

蛋白质网络架构极大地影响凝的特性.
质的功能与二硫化物键密切相关.
乙甲基酸盐 (EGCG) 是一种具有健康益处的强效多.

研究的目的:

为了研究受控的二硫化键裂变对EGCG-质复合凝的影响.
了解结构修改如何影响凝特性和功能.
优化EGCG-质共价凝特性,以提高生物活性和输送.

主要方法:

系统的代硫酸盐处理以诱导质中受控的二硫化物键裂变.
分析蛋白质展开,多结合和结构变化.
评价凝的机械强度,凝性质,热,pH和氧化稳定性.
对抗氧化活性和模拟胃肠道消化对EGCG释放和生物可访问性的评估.

主要成果:

适度的二硫化键裂解平衡了蛋白质展开和EGCG结合,产生了优越的凝强度.
渐进的裂变增强了质结构扩张和EGCG共价结合,改善了网络的一致性.
过度的裂变破坏了凝基因因过度交叉连接,降低了稳定性.
EGCG-质凝显示出高稳定性,强大的抗氧化活性,并在消化过程中持续释放EGCG.

结论:

精确调节二硫化键裂变是定制蛋白质-多聚烯共价凝特性的关键.
这种方法有效地提高了凝的物理化学特性,生物活性和营养物质的输送.
优化的EGCG-质凝为先进的功能性食品成分和生物活性输送系统提供了一个有希望的平台.

关键词:

生物可访问性生物可访问性共价复合体是一种共价复合体.解硫化物键裂变的发生.甲基甲基甲基甲酸甲基甲基甲基甲基甲酸甲酸甲酸甲酸甲酸甲酸甲酸凝凝凝是一种质蛋白是一种质.

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