CASCADE:一个社区参与的行动模式,用于在临床研究中产生快速,与患者相关的决策
1Department of Psychological Sciences, Purdue University, 703 3rd Street, West Lafayette, IN, 47906, USA. bkelleher@purdue.edu.
BMC medical research methodology
|July 2, 2025
概括
新的科学合作和决策的社区参与方法 (CASCADE) 方法有效地整合了患者和社区的意见,以便在临床试验中做出可行的研究决定.
科学领域:
- 临床试验方法论 临床试验方法论
- 以患者为中心的研究
- 社区参与科学活动
背景情况:
- 整合患者和社区的意见对于具有影响力的以患者为中心的研究至关重要.
- 对于产生患者知情的研究决策的技术有限.
- "科学合作与决策的社区参与方法" (CASCADE) 方法是为了弥补这一差距而开发的.
研究的目的:
- 描述新 CASCADE 方法的开发和实施.
- 在联邦资助的临床试验期间,做出可行的以患者为中心的研究决策.
- 评估CASCADE方法在活跃的临床试验中的可行性.
主要方法:
- 卡斯凯德方法整合了来自各种方法的技术,专注于七个主题支柱.
- 这些支柱包括:定义可行的目标,集中社区投入,整合预先注册和探索性分析,固定节奏调度,最小化认知偏见,集中多样性,并确保社区相关的,严格的和可行的决策.
- 该方法在一个活跃的临床试验中试行,以评估可行性指标,如参与,讨论主题,时间和输出量.
主要成果:
- 开幕式的CASCADE小组包括27名参与者,其中包括5名社区利益相关者,以改进远程医疗计划算法.
- 数据来源包括预先注册的分析,12个探索性"查询",患者输入和团队输入.
- 卡斯凯德支柱促进了18个初始假设和6个最终假设的产生,导致了19个决策变化.
结论:
- 在正在进行的临床试验中,CASCADE方法在快速,高效,以患者为中心的决策中被证明有效.
- 进一步的发展可以专注于最佳实践结构程序和加强前面板社区投入.
- 标准化CASCADE输出是未来探索的一个领域.
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