在腹膜透析中临床事件和患者报告的结果指标
Aruni Malaweera1,2, Louis L Huang3,4, Lawrence P McMahon3,4
1Department of Renal Medicine, Eastern Health 5, Arnold Street, Box Hill, 3128, Australia. aruni.malaweera@monash.edu.
BMC nephrology
|July 2, 2025
概括
腹腔透析 (PD) 患者的症状负担,通过息护理结果表 (POS-S) 症状-脏问卷进行测量,与传统的透析充分性标志物没有相关性. 较高的症状负担预示着较差的结果,包括死亡率和住院治疗.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 透析的充分性 透析的充分性
- 患者报告的结果措施 (PROMs)
背景情况:
- 腹膜透析 (PD) 中透析充分性的传统标志物与患者的症状和结果的相关性较差.
- 其余功能比传统的充足性标志物更好地决定了患者的症状和结果.
- 目前的指导方针建议将患者报告的结果措施 (PROM) 与透析充分性评估一起纳入.
研究的目的:
- 评估通过息护理结果尺度 (POS-S) 症状-脏问卷测量的症状负担是否与传统透析充分性标志物相关.
- 确定症状负担是否与未来患者的结果有关,包括死亡率,技术存活率和住院治疗.
主要方法:
- 对107名成人PD患者进行了回顾性研究.
- 在2周的窗口内,POS-S-脏问卷和常规腹腔平衡测试 (PET) -Adequest测试对联收集数据.
- 分析POS-S脏得分,充分度 (Kt/V,肌素清除) 和未来结果 (PD存活率,过渡到血液透析,移植,死亡) 之间的关联.
主要成果:
- 传统透析足够性标志物 (Kt/V,肌素清除率) 和症状负担 (POS-S脏评分) 之间没有发现相关性.
- 较高的症状负担与不太有利的结果显著相关:技术失败,住院和死亡 (p < 0.05).
- 增加的症状负担也与较低的血清白蛋白水平相关 (p < 0.001).
结论:
- 通过POS-S评分测量的症状负担与PD患者的传统透析充分性标志物无关.
- 较高的症状负担是不利结果的重要预测因素,包括技术失败,住院和死亡率.
- 像POS-S脏调查问卷一样,PROMs为例行PD评估提供了有价值的补充,提供了超越传统充足度措施的见解.
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