3型APS,孤立T1DM和LADY/LADA的临床和血清学特征
Yawei Qiu1, Lin Guo1, Hongyan Pan1
1Department of Endocrinology and Metabolism, Shenzhen University General Hospital, No. 1298, Xueyuan Avenue, Nanshan District, Shenzhen, 518055, China.
BMC endocrine disorders
|July 2, 2025
概括
3型自身免疫多分泌综合征 (APS) 与中国患者的单独1型糖尿病 (T1DM) 和潜伏自身免疫糖尿病 (LAD) 不同. 对于30岁以上的T1DM/LAD患者,特别是高GADAb的女性,建议对APS 3进行查.
科学领域:
- 内分泌学 在内分泌学.
- 自免疫性疾病 自免疫性疾病
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 在中国,对3型自身免疫多分泌综合征 (APS) 与单独的1型糖尿病 (T1DM),青少年潜在自身免疫糖尿病 (LADY) 和成人潜在自身免疫糖尿病 (LADA) 进行了有限的比较研究.
- 本研究通过描述和比较中国人口中的这些情况来解决这一差距.
研究的目的:
- 报告3型APS,T1DM,LADY和LADA的中国患者的临床和血清学特征.
- 为了在不同患者群体中比较这些特征.
主要方法:
- 从住院患者的临床和血清学数据的回顾性分析.
- 纳入标准:被诊断为3型APS,T1DM,LADY或LADA的患者.
主要成果:
- 分析了69名患者:18名3型APS患者,20名T1DM患者和31名LADY/LADA患者.
- 3型APS患者主要是女性,与T1DM/LADY/LADA组不同 (男性更多).
- 3型APS显示GADAb和甲状腺自身抗体水平较高;糖尿病和AITD可能同时发生或相隔数年.
结论:
- 与孤立的T1DM和LADY/LADA相比,3型APS呈现出明显的特征.
- 建议在30岁以上的T1DM/LADY/LADA患者中对APS 3进行查,特别是高GADAb的女性,包括甲状腺自身抗体检测.
- 建议对疑似或确诊的3型APS病例进行长期随访.
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