相关实验视频
Updated: Sep 17, 2025
10:46
Doppler Optical Coherence Tomography of Retinal Circulation
Published on: September 18, 2012
18.9K
脉冲葡萄糖皮质体治疗对有活性的格雷夫斯轨道病变患者视网膜血流的影响
Hedayatullah Mohammadi1, İrfan Botan Güneş2, Şeyhmus Arı3
1Department of Ophthalmology, Medicalpark Kocaeli Hospital, 41050, Kocaeli, Turkey.
BMC ophthalmology
|July 2, 2025
概括
静脉注射葡萄糖皮质体治疗增加了视网膜血液流动在活跃的Graves轨道病变 (GO) 的患者. 然而,血液流量仍然低于健康对照组,这表明活跃GO.的循环系统持续变化.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 医疗成像医学成像
背景情况:
- 格雷夫斯轨道病 (GO) 与视网膜血流减少有关.
- 葡萄糖皮质体治疗对活性GO视网膜血动力学的影响需要进一步研究.
研究的目的:
- 评估静脉注射甲基普雷迪尼索隆对有活性的GO患者视网膜血流的影响.
- 为了将GO患者的视网膜血流和黄斑厚度与健康对照进行比较.
主要方法:
- 使用OCT-Angiography测量了视网膜血液流动的表面和深层,外部视网膜毛细血管,和choriocapillaris.
- 在32名活跃的GO患者中,在甲基prednisolone治疗前和治疗后一周进行了测量.
- 还评估了中央黄斑厚度,眼内压力和视力敏度,并与32名健康对照人进行了比较.
主要成果:
- 与所有测量水平的对照组相比,在活跃的GO患者中,视网膜血流显著降低 (p < 0.001).
- 在治疗后,视网膜血流增加,但仍然明显低于对照组 (p < 0.001).
- 与对照组相比,活跃的GO患者在治疗前和治疗后的中央黄斑厚度显著增加 (p < 0.001).
结论:
- 脉冲葡萄糖皮质体治疗改善了在活跃的格雷夫斯轨道病的视网膜血流.
- 尽管接受了治疗,但GO患者的视网膜血流并没有完全恢复到健康人群中所见的水平.
- 在活跃的GO患者中,治疗后中央黄斑厚度仍然较高.
相关概念视频
01:27Open Angle Glaucoma: Treatment
586
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
586
01:28Angle Closure Glaucoma: Treatment
705
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
705
01:21Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
208
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
208
01:25Glaucoma: Overview
782
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
782
01:25Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
399
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
399