嗅觉功能的变化和血清中白素-6水平在急性阶段的双相I型精神障碍:一个纵向研究
Chunhong Yang1, Zhuohui Zhou1, Qiping Li1
1Department of Psychiatry, The Fourth People's Hospital of Shunde District (Shunde WuZhongpei Memorial Hospital), Foshan City, Guangdong, 528300, China.
BMC psychiatry
|July 2, 2025
概括
嗅觉敏感性 (OS) 和嗅觉识别 (OI) 在双相情感障碍 (BD) 患者中受损. 虽然OS随着缓解而恢复,但OI仍然受损,这表明它有可能作为BD活动和神经生物学特征的生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
背景情况:
- 双极性障碍 (BD) 是一种复杂的情绪障碍,其神经生物学基础不清楚.
- 调查潜在的生物标志物,如嗅觉功能和炎症标志物,可以提供对BD病理生理学的见解.
- 神经炎症,特别是IL-6在BD中的作用是正在进行的研究领域.
研究的目的:
- 为了比较双极性障碍患者 (躁狂,抑郁,情绪阶段) 和健康对照者之间的嗅觉功能 (灵敏度和识别) 和血清中白素-6 (IL-6) 水平.
- 探索疾病缓解期间嗅觉功能和IL-6水平的纵向变化.
- 评估BD患者的嗅觉功能和IL-6水平之间的相关性,以确定诊断和治疗疗效的潜在生物标志物.
主要方法:
- 横截面和纵向研究涉及50名躁狂BD患者,31名抑郁BD患者和59名健康对照.
- 嗅觉灵敏度 (OS) 和嗅觉识别 (OI) 用Sniffin' Sticks测试进行评估.
- 测量了血清IL-6水平,并跟踪患者,直到他们达到euthymic阶段.
主要成果:
- 无论是躁狂还是抑郁的BD患者,与健康对照人群相比,其OS和OI显著降低.
- 嗅觉敏感性 (OS) 在缓解后正常化,而嗅觉识别 (OI) 仍然受损.
- 血清IL-6水平随着躁狂BD患者的缓解而降低,但没有恢复到正常水平;躁狂BD患者的OS和IL-6之间发现了负相关性.
结论:
- OS的动态恢复表明其作为BD的疾病活动生物标志物的潜力,而持续的OI缺陷可能表明与特征相关的神经生物学特征.
- 这些发现表明,在躁狂性BD中,炎症活动和嗅觉功能障碍之间存在潜在的联系,需要进一步调查因果关系和机制.
- 需要进一步验证,以确定嗅觉功能和IL-6作为双相情感障碍生物标志物的特异性和临床实用性.
更多相关视频
相关概念视频
01:30Bipolar Disorder
150
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
150
01:24Mania and Antimanic Drugs: Overview
325
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
325
01:03Olfactory Receptors: Location and Structure
9.7K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
9.7K