身体活动,长寿基因和老年人全因死亡率:一个潜在的社区基队列研究
Lanjing Xu1,2, Jun Wang1,2, Xinwei Li1,2
1Key Laboratory of Environment and Population Health, Chinese Center for Disease Control and Prevention, National Institute of Environmental Health, Beijing, 100021, China.
BMC medicine
|July 2, 2025
概括
休活动,低强度的体力活动,显著降低了老年人的死亡风险,无论遗传倾向. 定期炼只对那些遗传寿命得分较高的人有好处.
科学领域:
- 老年学是指老年学的学科.
- 公共卫生 公共卫生
- 遗传学 是一个遗传学.
背景情况:
- 身体活动 (PA) 对老年人的健康至关重要,但最佳类型仍然不清楚.
- 本研究调查了不同PA对中国老年人死亡率的影响,考虑了遗传风险.
- 了解这些关联可以为个性化的健康建议提供信息.
研究的目的:
- 探索体力劳动,定期运动和休活动与全因死亡率之间的关联.
- 检查遗传风险对中国老年人这些关联的影响.
- 为了确定哪些类型的体育活动提供了最大的死亡率益处.
主要方法:
- 在中国长度健康长寿调查 (CLHLS,1998-2018) 中利用了9690名老年人的数据.
- 收集了关于体力劳动,定期炼和详细休活动的自我报告数据.
- 采用Cox的比例风险模型来分析PAS,遗传风险得分 (GRS) 和死亡率之间的关联.
主要成果:
- 高度休活动与低GRS个体的死亡率降低16%,高GRS个体的死亡率降低14%.
- 定期炼显示,高GRS个体的死亡率降低了11%,但低GRS个体的死亡率没有降低.
- 身体活动和长寿遗传学之间没有发现显著的相互作用.
结论:
- 以低强度和可访问性为特征的休活动似乎为老年人提供了相当大的死亡率好处.
- 这些好处扩展到具有较低遗传倾向的长寿个体.
- 个性化体育活动建议对于优化老年人群的健康结果至关重要.
相关概念视频
Longitudinal Research
12.5K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
12.5K
Lifestyle Factors and Health
132
Lifestyle factors play a critical role in maintaining overall health and preventing chronic diseases. Key elements, such as regular physical activity, a nutritious diet, and abstinence from smoking, can significantly enhance physical, mental, and emotional well-being while reducing the risk of several life-threatening conditions.
Benefits of Physical Activity
Physical activity, whether through structured exercise or casual activities like walking, biking, or dancing, is a cornerstone of a...
Benefits of Physical Activity
Physical activity, whether through structured exercise or casual activities like walking, biking, or dancing, is a cornerstone of a...
132
Longitudinal Studies
254
Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
254
The Effect of Aging on Tissues
2.6K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.6K
Aging
193
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
193
Mitochondria
15.1K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
15.1K


