相关实验视频
Updated: Sep 17, 2025

07:37
An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
Published on: June 6, 2025
375
风险因素和预测模型轻度认知障碍的老年患者与类风湿性关节炎
Jun Yan1, Hua Guo1, Lin-Xin Zhang2
1Department of Neurology, Xi'an Fifth Hospital, Xi'an, Shaanxi Province, China.
BMC rheumatology
|July 2, 2025
概括
较长的疾病持续时间,较高的炎症 (DAS28,CRP) 和骨质疏松症增加了老年类类风湿性关节炎患者轻度认知障碍的风险. 预测性名录图有助于早期检测及时干预.
科学领域:
- 类风湿病学 类风湿病学
- 老年病的医生 老年病的医生
- 神经科学是一个神经科学.
背景情况:
- 类风湿性关节炎 (RA) 是一种慢性自身免疫性疾病,导致关节损伤和全身炎症,影响生活质量.
- 轻度认知障碍 (MCI) 是痴呆症的前体,在老年RA患者中越来越多地观察到.
- 在RA患者中早期发现MCI对于及时干预减轻认知衰退至关重要.
研究的目的:
- 在老年RA患者中确定MCI的独立风险因素.
- 在这个人群中开发一个MCI风险分层的预测名录.
主要方法:
- 378名老年RA患者 (60-80岁) 用蒙特利尔认知评估 (MoCA) 评估认知功能.
- MCI被定义为MoCA分数在20-26之间.
- 后勤回归和名图构造被用来识别风险因素和预测MCI,模型性能通过ROC曲线,校准图和DCA.验证.
主要成果:
- 在378名患者中,有94名患者 (24.87%) 患有RA-MCI.
- 患有MCI的独立风险因素包括疾病持续时间长 (COD),疾病活动评分-28 (DAS28) 升高,高C反应蛋白 (CRP) 水平和骨质疏松症 (OP).
- 开发的名图显示了中度的预测歧视 (AUC=0.750).
结论:
- 疾病持续时间,骨质疏松症,DAS28和CRP水平是老年RA患者中MCI的显著预测因素.
- 命名图表作为早期风险评估的实用工具.
- 基于该工具的有针对性的干预措施可以帮助延缓RA患者的认知衰退.
更多相关视频
相关概念视频
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
70
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
70
Genome-wide Association Studies-GWAS
14.4K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
14.4K
Rheumatic Heart Disease I: Introduction
52
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
52
Rheumatic Heart Disease IV: Nursing Management
41
AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...
41
Rheumatic Heart Disease III: Medical Management
36
Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
36
Coronary Artery Disease I: Introduction
67
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
67

