佛萨普雷皮坦 (Fosaprepitant) 用于预防多天西斯普拉丁化疗引起的恶心和吐:一项前性随机对照研究
Lu Wang1, Gaowa Jin2, Wenjuan Wang2
1Ordos Clinical College, Inner Mongolia Medical University, Ordos, 017000, China.
BMC pharmacology & toxicology
|July 2, 2025
概括
与单独的三重疗法相比,福萨普雷皮坦特加三重疗法显著改善了化疗诱导的恶心和吐 (CINV) 控制. 这种组合疗法在接受基于的治疗的患者的常规和延迟治疗方案中都表现出优越性.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 临床试验 临床试验
背景情况:
- 化疗诱导的恶心和吐 (CINV) 仍然是接受癌症治疗的患者面临的重大挑战.
- 基于西斯普拉丁的化疗方案与CINV的高风险有关.
- 有效的抗策略对于改善患者的生活质量和治疗坚持至关重要.
研究的目的:
- 为了比较fosaprepitant加上三重治疗与单独三重治疗在预防CINV方面的疗效和安全性.
- 为了评估既常规和延迟的管理方案为fosaprepitant.
- 为了评估接受三天西斯普拉丁基化疗方案的患者的结果.
主要方法:
- 进行了一项前性随机对照试验.
- 患者接受了福萨普雷皮坦加三重疗法或单独的三重疗法.
- 在5天内评估了有效性和安全性,评估了CINV.的急性和延迟阶段.
主要成果:
- 在整体和延迟阶段 (分别为56.9%与40.4%和57.8%与40.4%) 中,佛萨普雷皮坦与三重疗法相加的三重疗法实现了明显更高的总保护 (TP) 率,而不是单独的三重疗法.
- 在延迟阶段,用福萨普雷皮坦 (fosaprepitant) 加上三重治疗的完全响应 (CR) 率也更高.
- 卡普兰-梅尔分析表明,福萨普雷皮坦加上三重疗法延迟了第一个吐发作的开始.
结论:
- 在接受为期三天的西斯普拉丁治疗的患者中,佛萨普雷皮坦特加三重疗法在控制CINV方面优于单独的三重疗法.
- 添加福萨普雷皮坦增强了抗保护,特别是在延迟阶段.
- 这种组合疗法代表了管理CINV的有效策略.
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