治疗急性老年疼痛和痴呆症的药理学干预措施:系统性审查
1Physical Examination Centre, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
概括
药理干预措施在预防痴呆症和治疗老年患者的急性疼痛方面显示出不同的结果. 联合的抗炎和疼痛管理策略可能比单个方法提供更好的结果.
科学领域:
- 老年医学 老年医学
- 药理学 药理学 是一个学科.
- 临床研究 临床研究
背景情况:
- 痴呆症和急性疼痛是老年住院患者的关键问题,与不良结果有关.
- 这些疾病会增加死亡率,功能衰退和住院时间.
研究的目的:
- 系统地审查和分析药理干预措施的有效性,以预防精神错乱和控制住院老年人的急性疼痛.
- 综合随机对照试验 (RCT) 和对照试验的发现.
主要方法:
- 在主要数据库 (PubMed,Scopus,Embase,Cochrane,Google Scholar,Web of Science) 进行了全面的文献搜索,截至2025年2月.
- 包括的研究包括RCT和对治疗住院老年患者妄预防或缓解疼痛的药物的受控试验.
- 数据被提取并分析了质量和数量上的妄和疼痛结果.
主要成果:
- 包括12项研究. 阴茎带块,抗炎包, gabapentin 和 butorphanol 有效地减少了疼痛和一些炎症标志物.
- 大多数药物对妄发生率没有显著影响,结果相互矛盾.
- 针对全身炎症的干预措施 (例如,甲基prednisolone,德克萨米他,手术前盐水) 显示出预防狂妄的前途.
结论:
- 单一的药理方法往往不足以预防老年患者的妄想.
- 结合策略,包括抗炎干预和有效的疼痛管理,可能会产生更好的结果.
- 未来的研究需要更大的样本大小,多样化的群体和标准化的测量工具.
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