Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Introduction to Mechanisms of Enzyme Catalysis01:13

Introduction to Mechanisms of Enzyme Catalysis

8.9K
For many years, scientists thought that enzyme-substrate binding took place in a simple "lock-and-key" fashion. This model stated that the enzyme and substrate fit together perfectly in one instantaneous step. However, current research supports a more refined view scientists call induced fit. The induced-fit model expands upon the lock-and-key model by describing a more dynamic interaction between enzyme and substrate. As the enzyme and substrate come together, their interaction causes...
8.9K
Enzymes02:34

Enzymes

82.8K
Inside living organisms, enzymes act as catalysts for many biochemical reactions involved in cellular metabolism. The role of enzymes is to reduce the activation energies of biochemical reactions by forming complexes with its substrates. The lowering of activation energies favor an increase in the rates of biochemical reactions.
Enzyme deficiencies can often translate into life-threatening diseases. For example, a genetic abnormality resulting in the deficiency of the enzyme G6PD...
82.8K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Deep learning-based frame synthesis enables radiation dose reduction in digital subtraction angiography imaging: a multicenter study.

Frontiers in medicine·2026
Same author

Case Report: A novel strategy for superior petrosal vein management in cerebellopontine angle surgery.

Frontiers in oncology·2026
Same author

The vertebro-subclavian artery angle modulates hemodynamic mechanisms of atherosclerosis in vertebral artery origin: a combined clinical and computational fluid dynamics study.

Frontiers in bioengineering and biotechnology·2026
Same author

Synthetic lethality in cancer: mechanism exploration and therapeutic applications.

Cell communication and signaling : CCS·2026
Same author

Defect-Rich RuCu Multilayered Nanosheets for Effective Alkaline Hydrogen Electrocatalysis.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

The transcription factor OsWRKY36 regulates leaf angle in rice by modulating brassinosteroid signaling.

The Plant cell·2026

相关实验视频

Updated: Sep 17, 2025

High Precision FRET at Single-molecule Level for Biomolecule Structure Determination
11:24

High Precision FRET at Single-molecule Level for Biomolecule Structure Determination

Published on: May 13, 2017

10.9K

空间协调结构驱动的单原子纳米酶中的类似酶的选择性

Qijun Sun1,2, Si Liu1, Ziping Li1

  • 1School of Chemical Engineering and Graduate School of Biomedical Engineering, The University of New South Wales, Sydney, NSW, 2052, Australia.

Advanced materials (Deerfield Beach, Fla.)
|July 2, 2025
PubMed
概括
此摘要是机器生成的。

单原子纳米酶 (SAzymes) 提供强大的催化剂,但缺乏选择性. 本次审查强调了设计协调结构以提高SAzyme对类似酶的反应的选择性.

关键词:
协调结构 协调结构密度函数理论密度函数理论具有类似酶的催化选择性.一个原子纳米酶,支持支持.

更多相关视频

Structural Information from Single-molecule FRET Experiments Using the Fast Nano-positioning System
12:30

Structural Information from Single-molecule FRET Experiments Using the Fast Nano-positioning System

Published on: February 9, 2017

12.3K
OaAEP1-Mediated Enzymatic Synthesis and Immobilization of Polymerized Protein for Single-Molecule Force Spectroscopy
08:34

OaAEP1-Mediated Enzymatic Synthesis and Immobilization of Polymerized Protein for Single-Molecule Force Spectroscopy

Published on: February 5, 2020

6.8K

相关实验视频

Last Updated: Sep 17, 2025

High Precision FRET at Single-molecule Level for Biomolecule Structure Determination
11:24

High Precision FRET at Single-molecule Level for Biomolecule Structure Determination

Published on: May 13, 2017

10.9K
Structural Information from Single-molecule FRET Experiments Using the Fast Nano-positioning System
12:30

Structural Information from Single-molecule FRET Experiments Using the Fast Nano-positioning System

Published on: February 9, 2017

12.3K
OaAEP1-Mediated Enzymatic Synthesis and Immobilization of Polymerized Protein for Single-Molecule Force Spectroscopy
08:34

OaAEP1-Mediated Enzymatic Synthesis and Immobilization of Polymerized Protein for Single-Molecule Force Spectroscopy

Published on: February 5, 2020

6.8K

科学领域:

  • 纳米材料科学 科学 纳米材料科学
  • 催化剂是一种催化剂.
  • 生物化学 生物化学

背景情况:

  • 单原子纳米酶 (SAzymes) 模仿自然酶,具有高活性和原子利用.
  • 目前的SA酶由于与天然酶相比,结构简化,具有有限的催化选择性.
  • 提高SA酶选择性对于它们作为酶替代品的更广泛应用至关重要.

研究的目的:

  • 审查改善SAzymes的催化选择性的策略.
  • 专注于SAzymes中的空间协调结构的合理设计.
  • 分析选择性SA酶的结构-活性关系和合成方法.

主要方法:

  • 审查SAzyme协调结构设计的文献.
  • 分析结构-活性关系,用于选择性催化.
  • 检查定制SAzyme结构的合成方法.

主要成果:

  • 空间协调结构显著影响SA酶的选择性.
  • 协调环境的合理设计可以实现有针对性的类似酶的选择性.
  • 特定的合成方法可以将设计结构集成到支上.

结论:

  • 设计协调结构是释放SAzyme选择性的关键.
  • 对SAzyme协调结构的进一步研究将推动下一代催化剂的开发.
  • 克服结构控制和合成方面的挑战对于推进SAzyme技术至关重要.