半固体矩阵对可扩散性,质和赛莱可西布释放率的影响
Urszula Bąk-Kuchejda1,2, Teresa Witczak3, Mariusz Witczak4
1Department of Pharmaceutical Technology and Biopharmaceutics, Jagiellonian University Medical College, Cracow, Poland.
Polimery w medycynie
|July 2, 2025
概括
切莱科克西布 (CEL) 局部配方在各种半固体基础上进行了评估. 像Celugel和Lekobaza这样的水友基显示出更快的CEL释放,适合不同的皮肤状况.
科学领域:
- 制药科学 制药科学
- 皮肤病学 皮肤病学
- 材料科学 材料科学 材料科学
背景情况:
- 塞莱科克西布 (CEL) 显示出治疗皮肤疾病的潜力.
- 目前还没有可用的局部半固体西莱科克西布配方.
研究的目的:
- 评估不同半固体矩阵对赛莱可西布在体外表现的影响.
- 为了指导未来的局部 Celecoxib 产品的发展.
主要方法:
- 切莱可西布 (1% w/w) 被纳入了四种化合物载体:莱科巴萨,莱科巴萨卢克斯,塞卢格尔和奥莱格尔.
- 评估了可扩散性,粘弹性和药物释放率.
- 研究了矩阵的物理化学特性对赛莱科克西布性能的影响.
主要成果:
- 所有经过测试的半固体矩阵都显示出适合于celecoxib的扩散性和rheological稳定性.
- 与疏水性矩阵 (Lekobaza Lux, Oleogel) 相比,水友性矩阵 (Celugel, Lekobaza) 促进了较高的赛莱可西布释放率.
- 粘性特性在Celugel中占主导地位,而弹性特性则在Lekobaza,Lekobaza Lux和Oleogel中占主导地位.
结论:
- 塞卢格尔是塞莱科克西布在治疗大,排泄性皮肤病变方面的有前途的载体.
- 在水凝涂抹后存在皮肤干燥的风险时,建议使用Lekobaza.
- 矩阵特性显著影响着赛莱科克西布释放动力学.
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