对疑似深静脉血栓形成的DAYS得分的外部验证
Thor-David Halstensen1,2, Camilla Hardeland1, Waleed Ghanima3,4
1Faculty of Health, Welfare and Organisation, Department of Nursing, Health and Laboratory Science, Østfold University College, Fredrikstad, Norway.
Research and practice in thrombosis and haemostasis
|July 2, 2025
概括
诊断深静脉血栓症 (DVT) 的两个新得分显示出低失败率,但超过了安全值. 这些DVT诊断工具需要进一步验证.
科学领域:
- 血管医学 血管医学
- 诊断的准确性 诊断的准确性
- 临床决策 - 临床决策
背景情况:
- 深静脉血栓 (DVT) 诊断依赖于临床评估,D-二次测试和成像.
- DAYS评分,一个带有D-二次元的2项工具,显示出有希望的结果,但需要外部验证.
研究的目的:
- 为了验证现有的DAYS评分和新开发的DVT预测评分.
- 在现实临床环境中评估这些评分的安全性和准确性.
主要方法:
- 挪威DVT管理研究 (2015-2018) 中1312名患者的前性数据.
- 评估DAYS评分 (2项) 和新的评分 (2项) 与威尔斯评分作为参考.
- 安全终点定义为DVT排除失败率<2%.
主要成果:
- 新的评分排除了39.6%的患者的DVT,失败率为1.3% (95% CI,0.5-2.8).
- 在DAYS得分中,不包括DVT的情况为34.6%,失败率为2.4% (95% CI,1.2-4.2).
- 这两个分数都超过了错过的DVT病例的2%安全值.
结论:
- 无论是DAYS评分还是新的2项评分,都显示DVT故障率很低.
- 然而,这两种预测工具都超过了预定义的安全边际,这表明潜在的诊断不足.
- 在这些DVT诊断分数得到广泛的临床采用之前,需要进一步的研究和改进.
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