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在登革热中,氧化应激诱导的肝损伤在肥胖患者中加剧

Heshan Kuruppu¹, Maneshka Karunananda¹, Chandima Jeewandara¹

¹Allergy, Immunology and Cell Biology Unit, Department of Immunology and Molecular Medicine, University of Sri Jayewardenepura, Nugegoda, Sri Lanka.

Open forum infectious diseases

|July 2, 2025

概括

肥胖与登革热患者的高肝酶和炎症有关. 氧化应激标志物如4-HNE和甲 (MDA) 在登革热病变发生过程中发挥了复杂的作用.

科学领域:

* 传染病传染病
* 肝病学肝病学是一门专业.
* 代谢障碍代谢障碍

背景情况:

* 关于急性登革热患者肥胖,肝功能障碍和氧化应激之间的关系的数据有限.
*本研究通过在多样化的队列中调查这些协会来解决知识差距.

研究的目的:

* 检查肥胖与肝功能障碍,氧化应激和登革热患者炎症标志物的相关性.
* 探索4-氨酸 (4-HNE) 和氨酸 (MDA) 在登革热病变中的作用.

主要方法:

*研究了577名成年登革热患者的队列,疾病持续时间≤4天.
*测量包括肝酶 (AST,ALT),C反应蛋白,费里丁,4-HNE,MDA,BMI和腰围.

主要成果:

*中心肥胖和较高的BMI与AST,ALT,CRP和费里水平的升高有关.
*4-HNE水平与AST和ALT相关,而MDA水平与AST,ALT和费里丁相反相关,在年轻,更瘦的个体中更高.
*没有观察到4-HNE或MDA在临床疾病严重程度方面存在显著差异.

结论:

* 肥胖与增加肝功能障碍和登革热炎症有关.
*4-HNE和MDA在登革热的发病过程中表现出不同的作用,因此需要进一步研究潜在的治疗点.

关键词:

登革热是因为登革热.急性肝衰竭是一种严重的肝衰竭.生物标志物生物标志物死亡率死亡率氧化应激是一种氧化应激.

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