体重指数和心血管代谢多病症之间的关系:系统性审查和元分析
Min Wu1, Yanyan Huang2, Qinyu Liu3
1Department of Nephrology, The People's Hospital of Yubei District, Chongqing, China.
Frontiers in cardiovascular medicine
|July 2, 2025
概括
超重和肥胖显著增加心血管代谢多病症 (CMM) 的风险. 控制体重对于预防和管理风险人群中CMM至关重要.
科学领域:
- 心脏病学 心脏病学
- 代谢健康 代谢健康
- 公共卫生 公共卫生
背景情况:
- 心血管代谢多病症 (CMM) 是一个重大的全球健康挑战.
- 了解身体质量指数 (BMI) 在CMM发展中的作用对于有效的预防和管理策略至关重要.
研究的目的:
- 系统地评估身体质量指数 (BMI) 和心血管代谢多病症 (CMM) 之间的关联.
- 综合观察性研究的证据,使用元分析来量化与不同BMI类别和连续BMI值相关的风险.
主要方法:
- 在多个数据库 (Cochrane Library,CINAHL,EMBASE,Web of Science,PubMed) 进行了全面的系统文献搜索,截至2024年5月16日.
- 包括11项涉及超过170万患者的观察性研究,10项研究为分析做出了贡献.
- 研究质量使用纽卡斯尔-太华尺度和AHRQ标准进行评估. 用R.中的"meta"包进行了元分析.
主要成果:
- 超重和肥胖都与CMM风险增加显著相关 (合并的ORs从3.52到3.68).
- 持续的BMI也显示出与CMM有显著的积极关联 (合并OR=2.90).
- 肥胖特别与更高的CMM风险有关 (HR = 3.27).
结论:
- 这一元分析证实了超重/肥胖和心血管代谢多病症之间的强烈正相关性.
- 公共卫生倡议应侧重于提高认识,促进高危人群 (如老年人,肥胖人群) 的查,并将体重管理纳入CMM护理计划.
相关概念视频
Obesity
624
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
624
Coronary Artery Disease I: Introduction
67
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
67
Assessment of the Cardiovascular System I: Subjective Data
472
A thorough health history and physical assessment are essential for identifying cardiovascular disease (CVD) symptoms and distinguishing them from other health issues.
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
472
Psychoneuroimmunology: Cardiovascular Disease
82
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
82
Blood Studies for Cardiovascular System I: Cardiac Biomarkers
352
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
352
Imaging Studies for Cardiovascular System IV: CMRI
140
Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
140


