对过敏性鼻炎中可变抗组胺反应的代谢洞察:揭示精确治疗的生物标志物
Xiaohong Lyu1,2, Yi Liu3, Hongna Li4
1Department of Allergy, Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic Diseases, National Clinical Research Center for Dermatologic and Immunologic Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
Frontiers in immunology
|July 2, 2025
概括
代谢学概况可以预测过敏性鼻炎 (AR) 对抗胰岛素药物的治疗反应. 在AR患者中,特定的代谢物和代谢途径,如咖啡因和酸盐代谢,在有效和无效的治疗组之间存在差异.
科学领域:
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
- 药物基因组学 药物基因组学
背景情况:
- 过敏性鼻炎 (AR) 对抗胰岛素药物的治疗反应在患者之间存在显著差异.
- 这种差异性反应的分子基础尚未完全理解.
- 识别生物标志物可以个性化AR管理.
研究的目的:
- 为了确定不同抗组胺反应的AR患者不同的代谢概况.
- 探索潜在的生物标志物,以预测AR中的抗组胺疗效.
- 为了深入了解AR治疗耐药性的代谢基础.
主要方法:
- 在57名AR患者中使用液态染色体质谱法 (LC-MS) 进行血清代谢分析.
- 分层分为抗组胺有效 (n=49) 和抗组胺无效 (n=8) 组.
- 分析包括临床表型,维生素D水平和mRNA表达 (H1R,TPSB).
主要成果:
- 高血H1R和鼻TPSBmRNA表达在抗胰岛素无效的AR患者中.
- 在两组之间确定了19种显著不同的代谢物 (p<0.05,折叠变化>2.0,VIP>1.0).
- 甲托雷克萨特,Pro-Val-Ala-Glu-Val和TyrMe-Ile-OH显示出高的诊断潜力 (AUC>0.70). 甲托雷克萨特,Pro-Val-Ala-Glu-Val和TyrMe-Ile-OH显示出高的诊断潜力 (AUC>0.70).
结论:
- 清晰的代谢特征区分抗组胺有效和无效的AR患者.
- 已识别的代谢物可以作为预测AR治疗反应的生物标志物.
- 研究结果表明,咖啡因和二的代谢途径参与了AR的抗组胺疗效.
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