Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

A Clinically Interpretable AI System for Real-Time Quality Control of Transthoracic Echocardiography: Development, Validation, and Deployment.

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography·2026
Same author

Privacy-Preserving Federated Deep Learning for Robust Anomaly Detection in Distributed Security Sensing Systems.

Sensors (Basel, Switzerland)·2026
Same author

Alternative splicing of WRKY55 orchestrates ABA signaling to enhance plant stress resistance.

Plant physiology·2026
Same author

Targeting S100A8/A9 Ameliorates Heart Failure with Preserved Ejection Fraction by Modulating TLR4/NF-κB-Mediated Inflammation.

Clinical and experimental pharmacology & physiology·2026
Same author

A case report of bevacizumab-induced subcapsular renal hemorrhage in a patient with lung adenocarcinoma.

Frontiers in oncology·2026
Same author

Strengths for adaptation: The roles of multidimensional social support and resilience in shaping loneliness trajectories among rural left-behind children.

Applied psychology. Health and well-being·2026

相关实验视频

Updated: Sep 17, 2025

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens
09:33

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens

Published on: August 25, 2023

1.3K

通过临床验证的E2F活动特征,精确预测神经母细胞瘤.

Donghan Cai1,2, Huihuang Xu1,2, Shiwei He3

  • 1Shengli Clinical Medical College, Fujian Medical University, Fuzhou, Fujian, China.

Frontiers in immunology
|July 2, 2025
PubMed
概括

基于E2F相关基因的新预后特征有效地分层了高风险神经母细胞瘤 (NB) 患者. 这个签名提供了潜在的生物标志物,用于改善NB的预后和向治疗.

关键词:
与E2F相关的基因药物敏感性 药物敏感性免疫系统是免疫系统的.神经母细胞瘤的神经母细胞瘤预后 预后 预后

更多相关视频

Zebrafish Model of Neuroblastoma Metastasis
05:20

Zebrafish Model of Neuroblastoma Metastasis

Published on: March 14, 2021

2.9K
Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
09:37

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells

Published on: August 25, 2021

1.9K

相关实验视频

Last Updated: Sep 17, 2025

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens
09:33

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens

Published on: August 25, 2023

1.3K
Zebrafish Model of Neuroblastoma Metastasis
05:20

Zebrafish Model of Neuroblastoma Metastasis

Published on: March 14, 2021

2.9K
Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
09:37

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells

Published on: August 25, 2021

1.9K

科学领域:

  • 儿科瘤学 儿科瘤学
  • 分子生物学分子生物学
  • 癌症基因组学 癌症基因组学

背景情况:

  • 神经母细胞瘤 (NB) 是最常见的儿童脑外固体瘤.
  • 高风险NB (HR-NB) 由于具有攻击性生物学和耐治疗性,其生存率很低.
  • 在NB中,E2F转录因子的预后和治疗作用尚不清楚.

研究的目的:

  • 在NB中识别E2F相关的分子亚型.
  • 开发和验证NB风险分层的预后签名.
  • 探索E2F相关亚型与瘤免疫微环境,突变负担和药物敏感性之间的关系.

主要方法:

  • 来自GEO,TARGET和E-MTAB-8248队列的转录数据的共识聚类.
  • 拉索回归用于构建和验证预后签名.
  • 使用CIBERSORT,ESTIMATE和GDSC数据库分析免疫透,瘤突变负担 (TMB) 和药物敏感性.

主要成果:

  • 四个与E2F相关的基因 (MAD2L1,CDC25A,CKS2,NME1) 形成了一个预后名录,将患者分为高风险和低风险组.
  • 低风险患者的整体存活率明显改善 (P<0.05).
  • 高风险组表现出较低的免疫/风脉得分,改变的免疫细胞透,明显的突变光谱和差异性的药物敏感性 (P < 0.001).

结论:

  • 与E2F相关的预后签名准确地分层了NB患者.
  • 这个签名作为一个潜在的生物标志物用于HR-NB的预后和向治疗.
  • 这些发现为NB瘤生物学,免疫格局和治疗策略提供了洞察力.