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局部晚期甲状腺癌的新辅助治疗:单一机构的经验

Ling-Feng Xu¹, Nuo Shi¹, Jia-Liang Niu¹

¹Department of Head and Neck Surgery, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Frontiers in oncology

|July 2, 2025

概括

包括氨酸激酶抑制剂 (TKI) 在内的新辅助疗法在局部晚期甲状腺癌中显示出有效性和安全性. 这种方法可以实现彻底的手术,潜在地改善患者的治疗结果和生存率.

科学领域:

在瘤学瘤学.
手术瘤学手术瘤学
医学瘤学医学瘤学

背景情况:

局部发达的甲状腺癌是一个积极的临床挑战,整体存活率 (OS) 很差.
新辅助疗法已成为改善这些患者治疗结果的潜在策略.
在新辅助治疗后评估手术的有效性和可行性至关重要.

研究的目的:

评估在局部晚期甲状腺癌患者的新辅助疗法后手术干预的有效性和可行性.
确定新辅助治疗对切除能力和患者预后的影响.

主要方法:

对16名在2019年1月至2024年6月期间接受治疗的局部晚期甲状腺癌患者的回顾性分析.
患者接受了新辅助疗法,包括铁氨酸激酶抑制剂 (TKI),免疫检查点抑制剂 (ICI) 或根据癌症亚型 (DTC,PDTC,ATC) 量身定制的化疗.
用RECIST 1.1评估瘤反应,使用卡普兰-梅尔法计算整体存活率.

主要成果:

在16名患者中,有10人接受了手术后的新辅助疗法.
目标应答率 (ORR) 为50.00%,疾病控制率 (DCR) 为81.25%.
在接受手术的患者中实现了50.00%的R0/1切除率;中位数的生存期为17个月,一些患者仍然没有复发.

结论:

新辅助疗法,包括TKI,ICI或化疗,对于局部晚期甲状腺癌是安全有效的.
这种治疗方式可以促进激进手术的机会.
新辅助治疗有望改善局部晚期甲状腺癌患者的预后.

关键词:

疾病控制率疾病控制率局部发达的甲状腺癌.作为一种新辅助治疗,新辅助治疗.客观的响应率客观的响应率这是一项回顾性研究.

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