静脉注射德克斯梅德托米丁与levobupivacaine对于对头骨针插入的血液动力反应
Aishwarya Srinivasan1, Shraddha Naik1, Jamale P B1
1Department of Anesthesiology, Krishna Institute of Medical Sciences, Krishna Vishwa Vidyapeeth (Deemed To Be University), Karad, Maharashtra, India.
Bioinformation
|July 2, 2025
概括
这项研究比较了头皮阻塞的静脉注射德克斯梅德托米丁和勒沃布皮瓦卡因,发现这两种药物都有效降低头骨针放置期间的血液动力学反应. 这两种麻醉方法在控制同情激活和紧张方面表现出相似的有效性.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
背景情况:
- 在手术期间的交感激活和紧张可以通过局部麻醉剂 (如levobupivacaine,fentanyl和静脉注射dexmedetomidine) 减轻.
- 将静脉注射德克斯梅德托米丁和莱沃布皮瓦卡因在控制血液动力学反应方面的疗效进行比较,具有临床意义.
研究的目的:
- 为了比较静脉注射德克斯梅德托米丁与levobupivacaine在减少同情激活和头骨针放置期间的血液动力学反应的疗效.
主要方法:
- 一项随机研究,涉及80名患者,分为两组 (D组:静脉注射德克斯梅德托米丁,S组:levobupivacaine).
- 血液动力学参数包括心率,平均动脉压,缩血压和腹缩血压在基线和在头骨针放置后的不同间隔内被测量.
- 在整个过程中,监测氧和度 (Spo2).
主要成果:
- 在基线,诱导期间或随后的任何时间点 (p > 0.05) 中,两组之间没有观察到氧和 (Spo2) 的显著差异.
- 芬太尼-莱沃布皮瓦卡因头皮阻断剂和静脉注射德克斯梅德托米丁在减轻对头骨针头部位的血液动力学反应方面表现出相似的有效性.
结论:
- 用芬太尼-莱沃布皮瓦卡因和静脉注射德克斯梅德托米丁进行头皮阻塞,在减少与头骨针头部位相关的血液动力学反应方面同样有效.
- 这两种麻醉策略都在涉及骨固定的神经外科手术过程中提供了对交感激活和紧张的可比控制.
相关概念视频
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia
597
Intravenous regional anesthesia or the Bier block technique is used to anesthetize a specific limb or extremity. It uses exsanguinated or blood-drained vessels to transport local anesthetics or LAs to the peripheral nerve trunks. Lidocaine without vasoconstrictors like epinephrine is most commonly used for this technique. Other drugs used are prilocaine, ropivacaine, and chloroprocaine. Bupivacaine is not recommended for this technique due to its high cardiac toxicity.
One of the advantages of...
One of the advantages of...
597
Parenteral Anesthetics: Overview
205
Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
205
Local Anesthetics: Clinical Application as Epidural Anesthesia
505
Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
505
Depolarizing Blockers: Pharmocokinetics
389
Depolarizing blockers are administered through intravenous injection. Succinylcholine is the most common choice of depolarizing blockers in emergency clinical practices. Although they have a rapid onset, they readily diffuse away from the motor end plate into the extracellular fluid. They are metabolized by enzymes such as liver butyrylcholinesterase and plasma pseudocholinesterases. This produces a short duration of action, typically 5-10 minutes long, unlike nondepolarizing blockers, which...
389
Local Anesthetics: Clinical Application as Spinal Anesthesia
808
Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
808
Drug Delivery: Parenteral Route
871
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
871


