电离辐射声学和超声波双模成像,用于在放射治疗期间可视化对解剖结构的剂量
Yaocai Huang1, Ibrahim Oraiqat2, Dale Litzenberg3
1Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States.
Photoacoustics
|July 2, 2025
概括
本研究引入了一种双模式成像系统,将电离辐射声学成像 (iRAI) 和超声波 (US) 结合起来,在放射治疗 (RT) 期间将辐射剂量沉积映射到解剖结构上. 该系统增强了实时可视化,提高了治疗准确度.
科学领域:
- 医学物理 医学物理
- 放射治疗技术的辐射疗法技术
- 生物医学成像学 生物医学成像学
背景情况:
- 对解剖结构的辐射剂量分布的准确可视化对于有效的放射治疗 (RT) 至关重要.
- 在RT期间实时跟踪解剖变化是当前成像模式的挑战.
研究的目的:
- 开发和评估一种双模体体积成像系统,用于在RT期间同时绘制辐射剂量沉积和解剖结构的地图.
- 在幻影和体内研究中评估系统的准确性和可行性.
主要方法:
- 开发一种双模式系统,将电离辐射声学成像 (iRAI) 和超声波 (US) 成像相结合.
- 使用具有自定义运动阶段的组织模仿幻影进行评估.
- 在子模型上的体内研究,以评估运动期间的剂量映射.
主要成果:
- 双模式系统提供实时,体积剂量对解剖学信息.
- 与独立的iRAI相比,美国校正提高了SSIM的0.51%和GPR的74.60%的剂量映射精度.
- 该系统成功地在体内绘制了辐射剂量沉积和运动诱导的变化.
结论:
- 开发的双模式成像系统是第一个在RT期间提供体积剂量对解剖学信息的系统.
- 这种技术显示了通过更好地调整辐射束,目标和处于风险的器官来增强RT结果的潜力.
- 需要进一步的临床验证才能充分发挥其在放射治疗中的潜力.
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