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Updated: Sep 17, 2025

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通过调节KIF20A,DEPDC1促进了脂肉瘤的恶性表型和疾病进展

Mingwei Yu1, Huishan Zhao2, Yujie Sun1

  • 1Department of Orthopedics, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.

Frontiers in endocrinology
|July 2, 2025
PubMed
概括

含有DEP域1 (DEPDC1) 的DEP域通过与KIF20A相互作用并激活PI3K/AKT/mTOR通路来促进脂肉瘤. 这种相互作用增强了细胞的增殖,迁移和入侵,导致患者的生存率降低.

关键词:
在DEPDC1中,它是DEPDC1.KIF20A KIF20A 的意思是在PI3K/AKT/mTOR中使用.脂肪肉瘤 (liposarcoma) 是一种恶性现象型的恶性现象型.

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