在接受腹腔透析的患者中建立长期感染的预测模型
Mengmeng Liu1, Qian Lu1, Jinzhu Sun1
1Department of Nephrology, Wuxi No.2 People's Hospital, Jiangnan University Medical Center, Wuxi, China.
Frontiers in medicine
|July 2, 2025
概括
腹腔透析 (PD) 感染与晚年,更长的手术切口和较低的预后营养指数 (PNI) 有关. 一种名谱模型有效地预测了PD患者的这些长期感染.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 传染性疾病 传染性疾病
- 医学统计 医学统计
背景情况:
- 腹腔透析 (PD) 感染是技术失败和死亡的主要原因.
- 识别风险因素和预测感染对于患者的治疗结果至关重要.
研究的目的:
- 确定长期PD相关感染的独立风险因素.
- 开发和验证这些感染的临床预测模型.
主要方法:
- 对214名接受PD治疗的末期病 (ESRD) 患者的回顾性分析.
- 感染 (n=67) 和非感染 (n=147) 队列之间的临床指标比较.
- 使用R软件进行多变量逻辑回归和名ogram构造.
主要成果:
- 高龄 (p=0.004),较长的外科切口长度 (p=0.018) 和较低的预后营养指数 (PNI,p<0.001) 是独立的风险因素.
- 诺莫格拉姆模型表现出良好的区分能力,AUC为0.807.
结论:
- 晚年,较长的手术切口和较低的PNI与PD感染有关.
- 开发的诺米图是预测PD患者长期感染风险的有效工具.
- 这个模型可以帮助临床医生早期识别高风险个体.
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