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循环血中CTRP3水平与急性缺血性中风之间的关联:系统性审查和元分析
Qingsheng Niu1,2,3, Ziyi Zhu3, Yaowen Jiang1,2
1Department of Emergency Medicine, West China Hospital of Sichuan University, Sichuan University, Chengdu, China.
Frontiers in neuroscience
|July 2, 2025
概括
在患有急性缺血性中风的患者中,C1q瘤坏死因子 (TNF) 相关蛋白3 (CTRP3) 的循环水平显著降低. 这一发现表明CTRP3可能在中风中发挥作用,年龄和BMI可能会影响这种关联.
科学领域:
- 生物化学 生物化学
- 神经科学是一个神经科学.
- 心血管研究研究心血管研究
背景情况:
- 与C1q瘤坏死因子 (TNF) 相关的蛋白3 (CTRP3) 是一种具有证明神经保护性质的新型阿迪波金.
- 有关急性缺血性中风 (AIS) 患者与健康个体的CTRP3水平存在矛盾的数据.
- 需要进行全面的元分析来澄清CTRP3和AIS之间的关联.
研究的目的:
- 系统地评估循环CTRP3水平与急性缺血性中风之间的关联.
- 解决有关AIS患者中CTRP3的现有文献中的差异.
主要方法:
- 在多个数据库 (PubMed,Web of Science,Embase等) 中进行了系统的文献搜索. 在2025年2月之前.
- 在对110个初始记录进行严格选后,包括了14篇相关文章.
- 进行了子组分析以调查异质性,并进行了出版偏差评估.
主要成果:
- 与对照组相比,急性缺血性中风患者的循环CTRP3水平显著降低 (Z = 6.04,P < 0.00001).
- 亚组分析确定了患者的年龄和体重指数 (BMI) 作为异质性的来源.
- 出版年份,临床参数,IL-6,CTRP9和并发症等因素无法解释观察到的异质性.
结论:
- 这一元分析证实了循环中CTRP3水平与急性缺血性中风之间存在显著的反向关联.
- 患者的年龄和BMI可能会调节CTRP3和AIS之间的关系.
- 较低的CTRP3水平可能代表缺血性中风的潜在生物标志物或治疗标.
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