用于制造含玻璃粉末和纤维的聚酸共基凝:结构,细胞相容性和表面生物活性研究
Chiara Cavazzoli1,2, Roberto Di Pasquale1, Zarrin Moghaddam1
1School of Chemistry and Chemical Engineering, University of Surrey, GU2 7XH Guildford, UK. d.carta@surrey.ac.uk.
Journal of materials chemistry. B
|July 2, 2025
概括
用添加酸基玻璃 (PGs) 在室温下通过协合成. 这些玻璃显示控制的释放和有希望的生物相容性,用于骨再生应用.
科学领域:
- 材料科学 材料科学 材料科学
- 生物材料工程 生物材料工程
- 生物医学应用 生物医学应用
背景情况:
- 酸盐基玻璃 (PG) 是用于药物输送和组织再生的可生物吸收材料.
- 传统的高温合成方法限制了PG的生物医学应用.
- 需要对PG进行可持续的室温合成技术.
研究的目的:
- 通过一种新的,可持续的室温联合化方法,合成含 (Mn) 的PG.
- 研究这些含Mn的PG在骨再生应用中的潜力.
- 评估合成的PG的Mn2+释放特征,体外生物相容性和初步生物活性.
主要方法:
- 以酸盐为基础的玻璃 (PGs) 在粉末 (PGPs) 和纤维 (PGFs) 形式使用以水为基础的化技术在室温下合成.
- 这些PG被添加了不同度的Mn2+ (0-10mol%).
- 评估了Mn2+释放,体外细胞毒性 (MTT试验) 和生物活性 (浸泡试验).
主要成果:
- 联合化方法成功地在室温下产生带有Mn的PGP和PGF.
- 随着较高的Mn2+负载,Mn2+释放量增加,表明可调节的释放动力学.
- 含有高达1mol%Mn2+的PGP和PGF对人类骨髓瘤细胞 (MG-63) 没有细胞毒性.
- 初步测试表明,Mn-doped PGs的表面可能会形成类似酸盐的酸盐相.
结论:
- 室温协是一种多功能和可持续的方法,用于生产带Mn的PG.
- 合成的Mn-dopedPG显示了受控的治疗离子释放和出色的生物相容性.
- 这些基于酸盐的新型眼镜是骨再生和控制药物输送系统的有希望的候选者.
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