抓住时机:PrEP选择和创新的潜力,以改变艾滋病毒预防
Heather-Marie A Schmidt1,2, Mateo Prochazka1, Heather Ingold1
1Global HIV, Hepatitis and STIs Programme, World Health Organization, Geneva, Switzerland.
Journal of the International AIDS Society
|July 2, 2025
概括
扩大艾滋病毒暴露前预防 (PrEP) 产品和输送方法的选择对于增加吸收和有效性至关重要. 提供多种选择,包括长效注射剂和差异化服务提供,可以帮助结束艾滋病毒流行.
科学领域:
- 公共卫生 公共卫生
- 预防传染病 预防传染病
- 艾滋病毒/艾滋病研究研究
背景情况:
- 口服暴露前预防 (PrEP) 是一种非常有效的艾滋病毒预防工具,但由于缓慢的推广和坚持的挑战,其全部潜力仍然没有得到实现.
- 目前的全球努力不足以实现2025年艾滋病毒预防目标,强调需要改进战略.
- 在PrEP产品和服务提供方面的创新对于提高获取,吸收,持久性和有效使用至关重要.
研究的目的:
- 讨论如何在PrEP产品和服务提供创新中提供选择,可以改变全球艾滋病毒预防.
- 突出新型长效注射PrEP配方和差异化服务交付 (DSD) 模型的潜力.
- 强调需要协调努力,以利用PrEP选择来结束艾滋病毒流行.
主要方法:
- 对现有和新兴PrEP产品和服务交付模式的评论和讨论.
- 审查现实世界的证据 PrEP 增加选择和 DSD 的影响.
- 分析扩大新PrEP干预措施的挑战和机遇.
主要成果:
- 长效注射PrEP (例如,卡博特格拉维尔,莱纳卡帕维尔) 可以解决与口服PrEP相关的挑战,例如坚持.
- 差异化服务提供 (DSD) 模式,包括以同行为主,以药房为基础和远程医疗,已经证明口服PrEP的成功和可接受性.
- 提供更多的PrEP选择和量身定制的服务提供推动了需求,并改善了预防覆盖率.
结论:
- 新时代的PrEP选择,包括长效产品和DSD,提供了一个显著的机会,以增加预防的访问和覆盖范围.
- 根据用户需求和偏好量身定制服务,将PrEP整合到其他服务中,并支持任务共享对于更广泛的覆盖范围至关重要.
- 如果未能利用PrEP选择并将其整合到艾滋病毒预防响应中,可能会延长艾滋病毒流行病的风险.
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