一个多学科的方法开发一种天然的抗真菌配方针对口腔 Candidiasis: 一个迷你回顾
Alaa T Rajkhan1, Odai I Medhesh2, Duaa Bafail2
1Department of Pharmaceutical Care, King Fahd General Hospital, Jeddah, Saudi Arabia.
Current pharmaceutical biotechnology
|July 2, 2025
概括
本综述提出了一种基于天然产品的新型抗真菌配方,用于口腔喉候群病 (OPC). 这种方法结合了天然化合物,先进的输送系统和计算方法,以快速,经济高效的药物开发.
科学领域:
- 菌类学和制药科学 菌类学和制药科学
- 自然产品化学 自然产品化学
- 计算机化药物发现技术
背景情况:
- 口腔膜候群病 (OPC) 显著影响免疫力低下和老年人群.
- 抗真菌耐药性和副作用的增加需要新的治疗策略.
- 目前对OPC的治疗方法受到耐药性和不良反应的限制.
研究的目的:
- 概述一个全面的策略,开发基于天然产品的新型抗真菌配方OPC.
- 探索粘粘性微乳液的使用,以提高药物输送和疗效.
- 整合计算方法,加速识别强效抗真菌剂.
主要方法:
- 关于PubMed,Scopus和Web of Science数据库的综合文献综述. 这是一本书.
- 搜索的术语包括"口腔菌病", "天然抗真菌剂", "黄", "粘粘性微乳液"和"计算药物发现".
- 在过去十年内发表的优先研究.
主要成果:
- 识别了具有对Candida物种证明抗真菌活性的天然化合物.
- 强调了诸如分子对接和in silico ADMET等计算工具在候选药物查中的实用性.
- 审查了验证配方安全性和有效性的体外/体内研究.
结论:
- 综合自然产品,计算方法和先进的传递系统的多学科方法对OPC治疗有希望.
- 这一战略有助于快速,经济高效地开发优化的抗真菌配方.
- 拟议的方法解决了OPC日益增长的挑战,特别是在脆弱的患者群体中.
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