在高海拔地区人口中解决贫血问题:全球影响,患病率,挑战和潜在解决方案
Ayoub Boulares1, Nicola Luigi Bragazzi2,3, Gustavo F Gonzales4
1Laboratory Mobility, Aging & Exercise-ER20296 (MOVE), Faculty of Sport Sciences-STAPS, University of Poitiers, Poitiers, France.
由于血红蛋白增加,贫血诊断在高海拔地区具有挑战性. 更新的标准和特定区域的方法对于在不同人群中准确的贫血评估和干预至关重要.
科学领域:
- 全球健康 全球健康
- 血液学 血液学 血液学
- 高度医学 高度医学
背景情况:
- 贫血影响全球四分之一的人口,对妇女和儿童产生重大影响.
- 高海拔地区的人群由于自然升高的血红蛋白水平,对贫血存在独特的诊断挑战.
- 目前世界卫生组织 (WHO) 的贫血截止值往往高估了高海拔地区的患病率,导致误诊.
研究的目的:
- 突出在高海拔地区人口中贫血的诊断挑战.
- 强调需要高度特定的贫血诊断标准.
- 探索在多样化,高海拔社区准确的贫血评估的潜在解决方案.
主要方法:
- 关于贫血患病率和高海拔地区的诊断现有文献的综述.
- 分析高度校正对贫血患病率的影响,特别是在南美儿童中.
- 检查高海拔人口 (如西藏人,埃塞俄比亚人) 的遗传适应.
主要成果:
- 世卫组织的标准贫血切线高估了高海拔人口中的贫血,导致误诊.
- 高度校正显著改变贫血患病率,特别是在儿童中.
- 遗传研究揭示了影响血红蛋白水平的特定人群适应性.
结论:
- 在高海拔地区,准确的贫血诊断需要更新,特定于人口的门值.
- 铁状况标记物,如血清肝素和基因研究提供的定制策略是潜在的解决方案.
- 解决社会经济因素和提高认识对于在多样化,高海拔环境中的有效贫血干预至关重要.
更多相关视频
07:24A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
03:35Determining Gender-Based Differences in Retinal and Choroidal Thickness in Underweight Individuals via Swept-Source Optical Coherence Tomography
Published on: December 1, 2023
相关概念视频
Factors Affecting Respiration
Factors Affecting Erythropoiesis
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
Heart Failure VI: Adjunct Therapies
The Periodic Table and Organismal Elements
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
Disorders of Erythrocytes
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
