在儿科卫生保健机构中操纵口服剂型的挑战和考虑:叙述性审查
M Paulsson1,2, R Hamre Svendsen3,4, J K N Andersen3
1Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Acta paediatrica (Oslo, Norway : 1992)
|July 2, 2025
概括
操纵儿科口服药物是常见的,导致剂量错误和伤害. 更安全的实践需要更好的配方,培训和新技术,如3D打印,以改善儿童患者的治疗结果.
科学领域:
- 儿科药理学 儿科药理学
- 制药技术 制药技术 制药技术
- 药物安全 药物安全
背景情况:
- 由于缺乏适合年龄的配方,许多儿科口服药物管理需要操纵.
- 这种做法很普遍,影响15%-37%的病例.
研究的目的:
- 调查儿童医疗保健中操纵固体口服剂型的挑战和风险.
- 提供建议,以提高儿童的安全性,疗效和患者的治疗结果.
主要方法:
- 从PubMed,Scopus和Web of Science (2000-2024) 的文献进行叙事审查.
- 包括监管指南和临床病例报告,重点关注儿童口服药物操纵,如剂量提取和分散片.
主要成果:
- 常见的操作,如分片和粉碎,导致剂量不准确,溶解度变化和药理动力学不一致.
- 在使用肠道食管的儿童或在处理不溶性药物时,风险增加,可能会造成伤害.
结论:
- 在儿科中广泛的口服药物操纵缺乏足够的基于证据的支持.
- 建议包括增加获得许可配方的机会,加强培训,并利用3D打印等先进制造技术.
- 监管协调和跨学科合作对于提高儿科药物安全性至关重要.
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