相关实验视频

Updated: Sep 17, 2025

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat

Published on: February 27, 2014

在CRSwNP中BDNF作为埃索诺菲尔炎症的关键调解者:从转录组和功能分析的见解

Qinqin Zhang^1,2, Jian Jiao^1,2, Sicen Pan^1,2

¹Department of Otolaryngology Head and Neck Surgery and Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China.

International forum of allergy & rhinology

|July 2, 2025

概括

大脑衍生神经营养因子 (BDNF) 在患有鼻多 (CRSwNP) 的慢性鼻炎时升高,促进了乙氨基基基活性和疾病严重程度. 针对BDNF途径可能为eosinophilic CRSwNP提供新的治疗方法.

科学领域:

免疫学免疫学免疫学
分子生物学分子生物学
耳鼻喉科耳鼻喉科耳鼻喉科

背景情况:

带有鼻息肉的慢性鼻炎 (CRSwNP) 的特征是由乙氨基酸驱动的炎症.
神经营养素在CRSwNP病变发生过程中的作用,就像来自大脑的神经营养素 (BDNF) 在CRSwNP病变过程中的作用,还不太清楚.

研究的目的:

在CRSwNP内型中研究BDNF表达.
为了确定BDNF水平,乙氨基酸透和临床严重程度之间的相关性.
阐明BDNF对乙氨基的调节机制和功能影响.

主要方法:

大量RNA测序和ELISA用于量化BDNF在鼻子组织和分泌物中的含量.
免疫光和单细胞RNA测序映射了细胞BDNF来源.
在人鼻上皮细胞和埃索诺菲尔的体外研究评估了BDNF的调节和功能.

主要成果:

乙DNF的表达在乙酸性CRSwNP (ECRSwNP) 中显著升高,与乙酸细胞数量和疾病严重程度相关.
通过JAK/STAT信号传递,IL-4/IL-13刺激增加了鼻上皮细胞中BDNF的产生.
外源BDNF通过激活TrkB受体,促进了乙氨基细胞的存活和迁移.

结论:

在CRSwNP中,BDNF充当了表皮质-色素相互作用的关键调解者.
该BDNF途径有助于持续的Th2驱动的炎症和氨酸细胞的持久性.
针对BDNF-TrkB轴为管理ECRSwNP提供了一个潜在的治疗策略.

关键词:

这就是为什么BDNF是BDNF.在CRSwNP中使用.Th2 细胞因子的产生.埃索诺菲尔性炎症是什么意思

更多相关视频

A BW Reporter System for Studying Receptor-Ligand Interactions

A BW Reporter System for Studying Receptor-Ligand Interactions

Published on: January 7, 2019

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation

Published on: May 30, 2020

相关概念视频

NF-κB-dependent Signaling Pathway

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...

Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal

Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal

Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.