在全身性硬化症中使用干细胞治疗
Lazaros I Sakkas1, Theodora Simopoulou2, Ioannis Alexiou3
1Faculty of Medicine, School of Health Sciences, University of Thessaly, 41110, Larissa, Greece. lsakkas@med.uth.gr.
Clinical rheumatology
|July 2, 2025
概括
系统性硬化症 (SSc) 治疗需要新的方法. 虽然干细胞疗法显示出前景,但介质干细胞 (MSC) 和它们的衍生物可能为SSc患者提供了精细的治疗策略.
科学领域:
- 免疫学和风湿病学
- 再生医学是一种再生医学.
- 纤维性疾病 纤维性疾病
背景情况:
- 系统性硬化症 (SSc) 是一种严重的自身免疫性疾病,以纤维化,微血管病变和自身抗体为特征,导致器官损伤和降低生活质量.
- 目前用于SSc的免疫抑制治疗方法不足,突出显示了大量未满足的治疗需求.
- 复杂的病原发生涉及适应性和先天性免疫细胞,特别是在早期的皮肤病变中.
研究的目的:
- 审查目前和新兴的系统性硬化症治疗策略.
- 评估自身造血干细胞移植 (aHSCT) 和介质干细胞 (MSC) 在管理SSc.的潜力.
- 探索MSC衍生的微微片作为一种精细的治疗替代方案.
主要方法:
- 审查有关SSc病原和治疗方式的现有文献.
- 对aHSCT对SSc.的有效性和局限性的分析.
- 评估MSC及其衍生物的免疫调节,抗纤维和血管新生特性.
主要成果:
- 自主造血干细胞移植 (aHSCT) 是SSc的可行选择,但需要标准化以尽量减少风险.
- 介质细胞干细胞 (MSCs) 由于其多方面的作用,显示出治疗潜力,但需要进一步精细化以获得临床应用.
- 从MSC衍生出的微微粒通过保留MSC功能而显示出前景,同时可能提供一种更安全,更易于管理的治疗方法.
结论:
- 在全身性硬化症治疗方面仍然存在大量未满足的需求,需要新的治疗策略.
- 基于干细胞的疗法,包括aHSCT和MSC,是有前途的途径,但需要优化.
- 从MSC衍生出的微片为SSc提供了潜在的优越治疗方法,需要进一步的研究和开发.
更多相关视频
10:10Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
Published on: November 8, 2016
8.9K
10:03Transplantation of Induced Pluripotent Stem Cell-derived Mesoangioblast-like Myogenic Progenitors in Mouse Models of Muscle Regeneration
Published on: January 20, 2014
9.8K
相关概念视频
01:22iPS Cell Differentiation
2.8K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
2.8K
01:21Stem Cell Therapy for Tissue Regeneration
4.2K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.2K
01:19Clinical Applications of Epidermal Stem Cells
2.8K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.8K
01:19Mesenchymal Stem Cells
5.0K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
5.0K
01:06Induced Pluripotent Stem Cells
4.4K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
Somatic...
4.4K
01:17Stem Cell Culture
5.4K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
5.4K