胃肠癌的新辅助治疗期间患者报告的结果及其与术后并发症的关联
Alexander H Shannon1, Samantha M Ruff1, Marilly Palettas1
1Division of Surgical Oncology, The Ohio State University Wexner Medical Center, 410 W 10Th Ave, N-907 Doan Hall, Columbus, OH, 43210, USA.
Journal of gastrointestinal cancer
|July 2, 2025
概括
在新辅助疗法 (NT) 期间,特定患者报告的结果 (PRO) 预测了胃肠道癌症患者的术后并发症. 早期的PRO监测可以指导干预措施以改善外科手术结果.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 患者报告的研究结果研究结果
背景情况:
- 对于胃肠道 (GI) 癌症的新辅助疗法 (NT) 可以导致不良事件.
- 在NT期间患者报告的结果 (PROs) 和生命质量 (QOL) 对术后并发症的预测价值仍然不清楚.
研究的目的:
- 调查NT期间的PRO和QOL是否预测肠道恶性瘤患者的术后并发症.
- 分析实时PROs,QOL和手术结果之间的关联.
主要方法:
- 一项前性队列研究分析了104名患有肠胃癌的患者,接受了NT.
- 一个手机应用程序收集了实时的PRO和每月的QOL (FACT-G).
- 单变量分析评估了PROs/QOL和术后Clavien-Dindo等级≥2并发症之间的关联.
主要成果:
- 在69名手术患者中,20名 (28.9%) 经历了30天的并发症.
- 两组之间在基线人口统计,NT持续时间或癌症类型方面没有发现显著差异.
- 与没有并发症的患者相比,患有并发症的患者报告了更多的食欲丧失和疼痛,但较少的疲劳,焦虑,睡眠障碍,注意力缺乏,抑郁和丧.
结论:
- 特定的PRO,如食欲丧失和疼痛,与胃肠道癌症患者的新辅助疗法后的术后并发症有关.
- 需要进一步的研究来探索手术前的PRO如何为以患者为中心的干预提供信息,以减轻术后并发症.
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