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在植入物和提取物中与双酸相关的骨硬化的风险:全国性基于人口的研究
Jin-Joo Yoo1, Jaeyeon Kim2, Min Jin Kang3
1Department of Prosthodontics, National Health Insurance Service- Ilsan Hospital, Goyang, South Korea.
Clinical oral investigations
|July 2, 2025
概括
与植入体手术或牙周治疗相比,拔牙显著增加了与双酸盐相关的骨缩 (BRONJ) 的风险. 长时间使用双酸盐和年龄较大增加了BRONJ风险,而毒品假期减少了它.
科学领域:
- 在口腔外科手术中.
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 双酸盐对于骨质疏松症的治疗至关重要,但会带来双酸盐相关的骨缩 (BRONJ) 的风险.
- 了解特定患者群体中的BRONJ发病率和风险因素对于临床决策至关重要.
研究的目的:
- 确定使用双酸盐的韩国骨质疏松症患者在牙科手术后的BRONJ的发生率和相关因素.
- 为了在不同的牙科手术中比较BRONJ风险.
主要方法:
- 利用韩国国家健康保险服务-国家健康信息数据库 (NHIS-NHID) 进行全国人口研究.
- 包括骨质疏松症患者 (2010-2018年),不包括患有特定癌症或疾病的患者.
- 使用诊断代码和治疗数据识别了BRONJ病例;使用后勤回归来分析风险因素.
主要成果:
- 在57,572名患者中,BRONJ的总发病率为0.43% (250例).
- 拔牙的发病率最高 (0.85%),其次是牙周治疗 (0.27%) 和植入式手术 (0.13%).
- 植入物外科手术 (OR=0.15) 和牙周治疗 (OR=0.32) 显示,比提取更低的BRONJ关联;年龄较大和使用双酸盐较长的时间增加了风险,而药物假期降低了风险.
结论:
- 拔牙的风险明显高于植入式手术或牙周治疗.
- 患者年龄和双酸盐治疗的持续时间是影响BRONJ发病率的关键因素.
- 较长的双酸盐药物持续时间与风险的增加有关,强调了毒品假期的重要性.
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