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Updated: May 3, 2026

Probing High-density Functional Protein Microarrays to Detect Protein-protein Interactions
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蛋白质微阵列的阵列式素化

Jacob Skallerup1, Thomas B G Poulsen1, Allan Stensballe2,3

  • 1Department of Health Science and Technology, Aalborg University, Aalborg, Denmark.

Methods in molecular biology (Clifton, N.J.)
|July 2, 2025
PubMed
概括

这项研究引入了一种在阵列上素化方法,以识别类风湿性关节炎 (RA) 中的新型自身抗原. 这种技术在体内复制了素化,有助于发现驱动自身免疫疾病的新型自身抗原.

关键词:
抗素蛋白抗体 (ACPA) 是一种抗素蛋白抗体.自动抗体简介自动抗体简介引定律化 引定律化氨酸 (Citrulline) 是一种氨酸.微阵列的微阵列新抗原是一种新抗原.新自抗原是一种新型自抗原.胆氨酸减小酶 (PAD) 是一种蛋白质微阵列中的蛋白质微阵列.类风湿性关节炎 类风湿性关节炎 类风湿性关节炎

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DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
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