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针对重症监护单位获得的弱点的生物标志物:用于预测,诊断和预后的系统性审查

Jiamei Song^1,2, Ting Deng^1,2, Qingmei Yu^1,2

¹Nursing Department, Affiliated Hospital of Zunyi Medical University, No. 149, Dalian Road, Huichuan District, Zunyi City, 563000, Guizhou Province, China.

Annals of intensive care

|July 2, 2025

概括

生物标志物对诊断和预测重症监护室获得的弱点 (ICU-AW) 在重症患者中显示出希望. 增长差异化因子-15显示出极好的效用,但需要进一步验证以获得临床应用.

科学领域:

临界护理医学临界护理医学
生物标志物发现发现
神经肌肉疾病神经肌肉疾病

背景情况:

在重症监护室获得的虚弱 (ICU-AW) 是一种常见的并发症,影响患者的治疗结果.
目前ICU-AW的诊断方法在接受和应用方面受到限制.
生物标志物为改善ICU-AW评估提供了潜力.

研究的目的:

系统地审查和综合关于ICU-AW诊断,预测和预后生物标志物的证据.
评估已识别的生物标志物的诊断和预测准确性.
为了确定有前途的生物标志物,以实现未来的临床实用性.

主要方法:

在多个数据库 (PubMed,Embase等) 进行系统的文献搜索. 在2025年1月之前.
使用纽卡斯尔-太华和QUADAS-2工具进行包含研究的质量评估.
提取生物标记特征,诊断标准和结果的数据.

主要成果:

涉及1176名患者的11项研究确定了10个潜在的ICU-AW生物标志物.
六个生物标志物显示出很强的准确性 (AUC>0.80),其中GDF-15显示出极好的效用性 (AUC ≥0.85).
四个生物标志物表现出中等准确度 (AUC 0.60-0.80).

结论:

十个生物标志物显示出ICU-AW评估的潜力,但临床效用是可变的.
大规模的前性研究对于验证至关重要.
先进的技术可以改进现有的生物标志物,并识别新的生物标志物.

关键词:

生物标志物生物标志物诊断诊断诊断诊断诊断在ICU获得的弱点.预测预测预测预测预后预测预测系统性审查系统性审查

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