增长差异化因子15预测了西班牙老年人的身体功能障碍:现实世界的前性研究
Karine Ferreira de Campos1, Esther García-Esquinas1,2,3, Antonio Buño-Soto4
1Department of Preventive Medicine and Public Health, School of Medicine, Universidad Autónoma de Madrid, Calle del Arzobispo Morcillo 4, 28029, Madrid, Spain.
GeroScience
|July 2, 2025
概括
较高水平的生长差异化因子15 (GDF15) 与老年人身体功能较差有关. 这一发现表明GDF15可能有助于识别与年龄相关的功能衰退风险的个体.
科学领域:
- 老年学是一门学科.
- 生物标志物 生物标志物
- 身体功能 身体功能
背景情况:
- 增长差异化因素15 (GDF15) 是一种疾病负担的新兴生物标志物.
- 很少有研究研究了GDF15与老年人客观测量的身体功能障碍之间的关联.
研究的目的:
- 评估血清GDF15水平与65岁及以上成年人身体功能受损之间的截面和纵向关联.
主要方法:
- 老年人-ENRICA-2队列包括2481名老年人.
- 血清GDF15在基线时被测量. 身体功能在基线和2.2年后使用经过验证的工具对下肢性能,敏捷性,移动性,软弱和脆弱性进行了评估.
- 进行了后勤回归分析,调整了潜在的混因素.
主要成果:
- 在所有评估措施中,更高的GDF15水平与普遍和发生的身体功能障碍有显著的关联,包括下肢表现,敏捷性,移动性,软弱和脆弱性.
- 在GDF15中,每25%增加的赔率比率在横截面分析中从1.06到1.24,在前性分析中从1.08到1.35.
- 这些关联甚至在没有心血管疾病或糖尿病的参与者中也保持一致.
结论:
- 高血清GDF15水平与老年人的现有和正在发展的身体功能障碍有关.
- GDF15显示出作为一个方便的生物标志物的潜力,用于识别处于功能衰退风险的老年人.
- 需要进一步的研究来探索GDF15的潜在机制,其在风险预测中的作用以及潜在的治疗干预措施.
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