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聚乙烯瓜尼丁化和聚乙烯比古安化对导致牛乳炎的微生物的体外抗菌活性

Gustavo Lima Ribeiro¹, Sérgio Ricardo Ambrósio², Renato Luis Tame Parreira²

¹Centro Universitário do Cerrado de Patrocínio (UNICERP), Parque Universitário, Av. Líria Terezinha Lassi Capuano, 466, Patrocínio, CEP 38.747-792, MG, Brazil.

Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]

|July 2, 2025

概括

新的合成聚合物,聚乙烯瓜尼丁化 (PHMGH) 和聚乙烯比古安化 (PHMB),在体外对牛乳炎病原体表现出强烈的抗菌活性. 这些化合物有效地抑制了细菌生长和生物膜的形成,为新的乳液健康产品提供了潜力.

科学领域:

兽医微生物学兽医微生物学
抗菌剂抗菌剂抗菌剂
牛的健康问题

背景情况:

牛乳腺炎由于耐药性和动物感染性病原体而带来了重大的经济和公共卫生挑战.
有效的抗微生物策略对于管理牛乳炎和确保牛奶安全至关重要.

研究的目的:

评估聚乙烯瓜尼丁化 (PHMGH) 和聚乙烯比古安化 (PHMB) 对关键牛乳腺炎病原体的体外抗菌疗效.
为了比较PHMGH和PHMB与化 (BKC) 的活性,并评估它们对细菌生长,生物膜形成和动力学的影响.

主要方法:

进行了最小抑制度 (MIC) 和最小杀菌度 (MBC) 测试.
使用了分数抑制度指数 (FICI),杀菌动力学和生物膜抑制最小抑制度 (CIMB75).
标准和临床分离的黄金葡萄球菌, Staphylococcus epidermidis,Streptococcus agalactiae,Streptococcus dysgalactiae,和大肠杆菌被测试了.

主要成果:

在低度 (0.39.6 ppm) 中,PHMGH和PHMB对所有测试细菌表现出强烈的抗菌活性.
这两种聚合物都表现出快速的杀菌动力学,迅速减少了90%以上的微生物负载.
PHMGH和PHMB有效地抑制了生物膜的形成,PHMGH显示出更高的疗效.

结论:

在体外,PHMGH和PHMB对引起牛乳腺炎的病原体具有很高的效果.
这些合成聚合物为开发用于牛乳腺炎的新型预防和治疗产品提供了有希望的替代品.

关键词:

临床乳腺炎是一种临床乳腺炎.在浸泡后进行后浸泡.在浸泡前进行预浸泡合成聚合物合成聚合物

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