社区水三甲和慢性病
Danielle N Medgyesi1, Sumit Mohan2,3, Komal Bangia4
1Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York.
JAMA network open
|July 2, 2025
概括
长期暴露于社区供水中的三甲,特别是化合物,与慢性病 (CKD) 的风险增加有关. 即使低于当前美国标准的水平也可能构成健康风险,突出了潜在的公共卫生问题.
科学领域:
- 环境健康 环境健康
- 流行病学 流行病学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 美国的社区供水 (CWS) 主要使用进行消毒,导致三甲 (THM) 副产品.
- THM与膀癌和不良出生结果有关;动物研究表明脏受损,但人类数据有限.
研究的目的:
- 调查住院CWS中长期暴露于THM和患慢性病 (CKD) 的风险之间的关联.
主要方法:
- 分析了加利福尼亚州89,320名女教师 (1995-2018) 的前性队列研究.
- 计算了四种THM的时间加权平均度,包括化THM和.
- 考克斯的比例危险回归模型评估了与THM暴露水平相关的CKD风险.
主要成果:
- 在THM和CKD风险之间观察到显著的暴露-反应关联,特别是化THM.
- 对CKD的危险比率随着更高的化THM暴露而增加,HR分别在75百分位和95百分位以上为1.23和1.43.
- 在包括和在内的混合物分析中,化THM是CKD风险的主要贡献者.
结论:
- 低于当前美国标准 (80μg/L) 的THM暴露与该队列中CKD风险增加有关.
- 缺乏单独监管的化THM似乎是CKD的重要风险因素.
- 调查结果表明,由于水的广泛化和CKD负担的增加,可能会对公共卫生产生潜在影响.
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